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Mouse Anti-RPL11 Recombinant Antibody (2A1) (CBMAB-R3349-CN)

This product is a Mouse antibody that recognizes RPL11. The antibody 2A1 can be used for immunoassay techniques such as: WB, IP, IF, IHC-P, ELISA.
See all RPL11 antibodies
Published Data
Fig. 1 Fluorescence in situ hybridization of a PAC clone containing RPL11 to human metaphase chromosomes. Fluorescent spots are visualized at 1p36.1→p35 by comparing the FISH (a,c) and the GTG-banding (b, d) results (two cells).
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Fig. 2 L11 induces a p53-dependent cell cycle arrest in normal human fibroblast cells.
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Fig. 3 Fluctuation of L11 protein levels correlates with p53 levels under physiological growth inhibitory conditions.
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Fig. 4 Cells depleted of RPL11 or RPL5 progress through the cell cycle more slowly than control cells.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
2A1
Application
WB, IP, IF, IHC-P, ELISA

Basic Information

Specificity
Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Target

Full Name
Ribosomal Protein L11
Introduction
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L5P family of ribosomal proteins. It is located in the cytoplasm. The protein probably associates with the 5S rRNA. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Dec 2010]
Entrez Gene ID
6135
UniProt ID
P62913
Alternative Names
Ribosomal Protein L11; Large Ribosomal Subunit Protein UL5; CLL-Associated Antigen KW-12; Cell Growth-Inhibiting Protein 34; 0S Ribosomal Protein L11; GIG34; DBA7; L11;
Function
Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:32669547, PubMed:19191325).
The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules (PubMed:32669547, PubMed:19191325).
The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain (PubMed:32669547, PubMed:19191325).
The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (PubMed:32669547, PubMed:19191325).
As part of the 5S RNP/5S ribonucleoprotein particle it is an essential component of the LSU, required for its formation and the maturation of rRNAs (PubMed:19061985, PubMed:12962325, PubMed:24120868).
It also couples ribosome biogenesis to p53/TP53 activation. As part of the 5S RNP it accumulates in the nucleoplasm and inhibits MDM2, when ribosome biogenesis is perturbed, mediating the stabilization and the activation of TP53 (PubMed:24120868).
Promotes nucleolar location of PML (By similarity).
Biological Process
Biological Process cytoplasmic translationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of proteasomal ubiquitin-dependent protein catabolic processISS:UniProtKB
Biological Process negative regulation of protein neddylationManual Assertion Based On ExperimentIDA:CAFA
Biological Process negative regulation of ubiquitin protein ligase activityManual Assertion Based On ExperimentIMP:CAFA
Biological Process negative regulation of ubiquitin-dependent protein catabolic processManual Assertion Based On ExperimentIMP:CAFA
Biological Process positive regulation of gene expressionManual Assertion Based On ExperimentIDA:CAFA
Biological Process positive regulation of intrinsic apoptotic signaling pathway by p53 class mediatorIEA:Ensembl
Biological Process positive regulation of protein bindingManual Assertion Based On ExperimentIMP:CAFA
Biological Process protein localization to nucleusISS:UniProtKB
Biological Process protein stabilizationManual Assertion Based On ExperimentIMP:CAFA
Biological Process protein targetingManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of signal transduction by p53 class mediatorManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process ribosomal large subunit assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process ribosomal large subunit biogenesisManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process rRNA processingManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process translationManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Nucleus, nucleolus
Cytoplasm
Involvement in disease
Diamond-Blackfan anemia 7 (DBA7):
A form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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