Mouse Anti-RPL11 Recombinant Antibody (CBCNR-704) (CBMAB-R3351-CN)

Ribosomal Protein L11

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L5P family of ribosomal proteins. It is located in the cytoplasm. The protein probably associates with the 5S rRNA. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Dec 2010]

Ribosomal Protein L11; Large Ribosomal Subunit Protein UL5; CLL-Associated Antigen KW-12; Cell Growth-Inhibiting Protein 34; 0S Ribosomal Protein L11; GIG34; DBA7; L11;

Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:32669547, PubMed:19191325).
The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules (PubMed:32669547, PubMed:19191325).
The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain (PubMed:32669547, PubMed:19191325).
The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (PubMed:32669547, PubMed:19191325).
As part of the 5S RNP/5S ribonucleoprotein particle it is an essential component of the LSU, required for its formation and the maturation of rRNAs (PubMed:19061985, PubMed:12962325, PubMed:24120868).
It also couples ribosome biogenesis to p53/TP53 activation. As part of the 5S RNP it accumulates in the nucleoplasm and inhibits MDM2, when ribosome biogenesis is perturbed, mediating the stabilization and the activation of TP53 (PubMed:24120868).
Promotes nucleolar location of PML (By similarity).

Biological Process cytoplasmic translationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of proteasomal ubiquitin-dependent protein catabolic processISS:UniProtKB
Biological Process negative regulation of protein neddylationManual Assertion Based On ExperimentIDA:CAFA
Biological Process negative regulation of ubiquitin protein ligase activityManual Assertion Based On ExperimentIMP:CAFA
Biological Process negative regulation of ubiquitin-dependent protein catabolic processManual Assertion Based On ExperimentIMP:CAFA
Biological Process positive regulation of gene expressionManual Assertion Based On ExperimentIDA:CAFA
Biological Process positive regulation of intrinsic apoptotic signaling pathway by p53 class mediatorIEA:Ensembl
Biological Process positive regulation of protein bindingManual Assertion Based On ExperimentIMP:CAFA
Biological Process protein localization to nucleusISS:UniProtKB
Biological Process protein stabilizationManual Assertion Based On ExperimentIMP:CAFA
Biological Process protein targetingManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of signal transduction by p53 class mediatorManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process ribosomal large subunit assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process ribosomal large subunit biogenesisManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process rRNA processingManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process translationManual Assertion Based On ExperimentTAS:ProtInc

Nucleus, nucleolus
Cytoplasm

Diamond-Blackfan anemia 7 (DBA7):
A form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies.