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Mouse Anti-RPS7 Recombinant Antibody (3G4) (CBMAB-R3595-CN)

This product is a Mouse antibody that recognizes RPS7. The antibody 3G4 can be used for immunoassay techniques such as: WB, ELISA, IHC-P, FC, IF.
See all RPS7 antibodies

Summary

Host Animal
Mouse
Specificity
Mouse, Human
Clone
3G4
Antibody Isotype
IgG1
Application
WB, ELISA, IHC-P, FC, IF

Basic Information

Specificity
Mouse, Human
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration
1 mg/mL

Target

Full Name
ribosomal protein S7
Introduction
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S7E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
Entrez Gene ID
Human6201
Mouse20115
UniProt ID
HumanP62081
MouseP62082
Alternative Names
Ribosomal Protein S7; Small Ribosomal Subunit Protein ES7; 40S Ribosomal Protein S7; DBA8; S7;
Function
Required for rRNA maturation.
Biological Process
Biological Process cytoplasmic translation1 PublicationIC:FlyBase
Biological Process negative regulation of ubiquitin protein ligase activityManual Assertion Based On ExperimentIDA:CAFA
Biological Process negative regulation of ubiquitin-dependent protein catabolic processManual Assertion Based On ExperimentIDA:CAFA
Biological Process neural crest cell differentiationIEA:Ensembl
Biological Process neural tube closureIEA:Ensembl
Biological Process positive regulation of gene expressionManual Assertion Based On ExperimentIMP:CAFA
Biological Process positive regulation of intrinsic apoptotic signaling pathway by p53 class mediatorManual Assertion Based On ExperimentIMP:CAFA
Biological Process protein stabilizationManual Assertion Based On ExperimentIMP:CAFA
Biological Process ribosomal small subunit biogenesisManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process rRNA processingManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process translation1 PublicationNAS:UniProtKB
Cellular Location
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Cytoplasm
Nucleus
Although RPS7 is functional within the cytoplasm, the assembly of ribosomal subunits occurs in the nucleus. RPS7 nuclear import is mediated by IPO5/RanBP5, IPO7/RanBP7, KPNB1/importin-beta or TPNO1/Trn (PubMed:9687515).
Colocalizes with NEK6 in the centrosome (PubMed:20873783).
Involvement in disease
Diamond-Blackfan anemia 8 (DBA8):
A form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies.
PTM
Phosphorylated by NEK6.
Ubiquitinated. Deubiquitinated by DESI2, leading to its stabilization.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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