Mouse Anti-RRN3 Recombinant Antibody (3H5) (CBMAB-R3701-CN)

Name: Mouse Anti-RRN3 Recombinant Antibody (3H5)
SKU: CBMAB-R3701-CN
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

3H5

Application

ELISA, WB

Immunogen

Partial recombinant corresponding to aa. 525-632 from human RRN3 (NP_060897) with GST tag

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.2

More Infomation

Target

Full Name

RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae)

Introduction

RRN3 (RRN3 Homolog, RNA Polymerase I Transcription Factor) is a Protein Coding gene. Among its related pathways are Gene Expression and RNA Polymerase I Promoter Escape. Gene Ontology (GO) annotations related to this gene include binding and RNA polymerase binding.

Entrez Gene ID

54700

UniProt ID

Q9NYV6

Alternative Names

RRN3 Homolog, RNA Polymerase I Transcription Factor; Transcription Initiation Factor IA; TIF-IA; TIFIA; RRN3 RNA Polymerase I Transcription Factor Homolog (S. Cerevisiae); RNA Polymerase I-Specific Transcription Initiation Factor RRN3;

Function

Required for efficient transcription initiation by RNA polymerase I. Required for the formation of the competent preinitiation complex (PIC). Dissociates from pol I as a consequence of transcription. In vitro, cannot activate transcription in a subsequent transcription reaction (By similarity).

Biological Process

Biological Process cytoplasm organizationIEA:Ensembl
Biological Process fibroblast proliferationIEA:Ensembl
Biological Process homeostasis of number of cellsIEA:Ensembl
Biological Process in utero embryonic developmentIEA:Ensembl
Biological Process intrinsic apoptotic signaling pathway by p53 class mediatorIEA:Ensembl
Biological Process negative regulation of intrinsic apoptotic signaling pathway by p53 class mediatorIEA:Ensembl
Biological Process nucleolus organizationIEA:Ensembl
Biological Process positive regulation of DNA-templated transcriptionIEA:Ensembl
Biological Process regulation of DNA-templated transcription initiationIEA:Ensembl
Biological Process ribosome biogenesisIEA:Ensembl
Biological Process transcription initiation at RNA polymerase I promoterManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Nucleus, nucleolus

PTM

Phosphorylation is required for participation in rDNA transcription (By similarity).
Phosphorylated at Thr-200 by MAPK9/JNK2, which abrogates initiation complex formation

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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