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Mouse Anti-RRN3 Recombinant Antibody (3H5) (CBMAB-R3701-CN)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
3H5
Antibody Isotype
IgG1, κ
Application
ELISA, WB

Basic Information

Immunogen
Partial recombinant corresponding to aa. 525-632 from human RRN3 (NP_060897) with GST tag
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2

Target

Full Name
RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae)
Introduction
RRN3 (RRN3 Homolog, RNA Polymerase I Transcription Factor) is a Protein Coding gene. Among its related pathways are Gene Expression and RNA Polymerase I Promoter Escape. Gene Ontology (GO) annotations related to this gene include binding and RNA polymerase binding.
Entrez Gene ID
54700
UniProt ID
Q9NYV6
Alternative Names
RRN3 Homolog, RNA Polymerase I Transcription Factor; Transcription Initiation Factor IA; TIF-IA; TIFIA; RRN3 RNA Polymerase I Transcription Factor Homolog (S. Cerevisiae); RNA Polymerase I-Specific Transcription Initiation Factor RRN3;
Function
Required for efficient transcription initiation by RNA polymerase I. Required for the formation of the competent preinitiation complex (PIC). Dissociates from pol I as a consequence of transcription. In vitro, cannot activate transcription in a subsequent transcription reaction (By similarity).
Biological Process
Biological Process cytoplasm organizationIEA:Ensembl
Biological Process fibroblast proliferationIEA:Ensembl
Biological Process homeostasis of number of cellsIEA:Ensembl
Biological Process in utero embryonic developmentIEA:Ensembl
Biological Process intrinsic apoptotic signaling pathway by p53 class mediatorIEA:Ensembl
Biological Process negative regulation of intrinsic apoptotic signaling pathway by p53 class mediatorIEA:Ensembl
Biological Process nucleolus organizationIEA:Ensembl
Biological Process positive regulation of DNA-templated transcriptionIEA:Ensembl
Biological Process regulation of DNA-templated transcription initiationIEA:Ensembl
Biological Process ribosome biogenesisIEA:Ensembl
Biological Process transcription initiation at RNA polymerase I promoterManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Nucleus, nucleolus
PTM
Phosphorylation is required for participation in rDNA transcription (By similarity).
Phosphorylated at Thr-200 by MAPK9/JNK2, which abrogates initiation complex formation
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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