RRN3

RRN3 (RRN3 Homolog, RNA Polymerase I Transcription Factor) is a Protein Coding gene. Among its related pathways are Gene Expression and RNA Polymerase I Promoter Escape. Gene Ontology (GO) annotations related to this gene include binding and RNA polymerase binding.

Full Name

RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae)

Function

Required for efficient transcription initiation by RNA polymerase I. Required for the formation of the competent preinitiation complex (PIC). Dissociates from pol I as a consequence of transcription. In vitro, cannot activate transcription in a subsequent transcription reaction (By similarity).

Biological Process

Biological Process cytoplasm organizationIEA:Ensembl
Biological Process fibroblast proliferationIEA:Ensembl
Biological Process homeostasis of number of cellsIEA:Ensembl
Biological Process in utero embryonic developmentIEA:Ensembl
Biological Process intrinsic apoptotic signaling pathway by p53 class mediatorIEA:Ensembl
Biological Process negative regulation of intrinsic apoptotic signaling pathway by p53 class mediatorIEA:Ensembl
Biological Process nucleolus organizationIEA:Ensembl
Biological Process positive regulation of DNA-templated transcriptionIEA:Ensembl
Biological Process regulation of DNA-templated transcription initiationIEA:Ensembl
Biological Process ribosome biogenesisIEA:Ensembl
Biological Process transcription initiation at RNA polymerase I promoterManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Nucleus, nucleolus

PTM

Phosphorylation is required for participation in rDNA transcription (By similarity).
Phosphorylated at Thr-200 by MAPK9/JNK2, which abrogates initiation complex formation