Mouse Anti-RTRAF Recombinant Antibody (CBWJC-4391) (CBMAB-C5772WJ)

Name: Mouse Anti-RTRAF Recombinant Antibody (CBWJC-4391)
SKU: CBMAB-C5772WJ
Rating: 5 (1 reviews)

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Datasheet

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Basic Information

Host Animal

Mouse

Clone

CBWJC-4391

Application

IHC

Immunogen

Full length human recombinant protein of human C14orf166 (NP_057123) produced in E.coli

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS (PH 7.3), 1% BSA, 50% glycerol

Preservative

0.02% sodium azide

Concentration

1 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

RNA Transcription, Translation And Transport Factor

Introduction

RTRAF (RNA Transcription, Translation And Transport Factor) is a Protein Coding gene. Diseases associated with RTRAF include Influenza and Leukoencephalopathy With Vanishing White Matter. Among its related pathways are Gene Expression and tRNA processing.

Entrez Gene ID

51637

UniProt ID

Q9Y224

Alternative Names

RNA Transcription, Translation And Transport Factor; RLL Motif Containing 1; CLE7 Homolog; C14orf166; HCLE; CLE; RNA Transcription, Translation And Transport Factor Protein; Chromosome 14 Open Reading Frame 166;

Function

RNA-binding protein involved in modulation of mRNA transcription by Polymerase II (PubMed:16950395).
Component of the tRNA-splicing ligase complex and is required for tRNA ligation (PubMed:24870230).
May be required for RNA transport (PubMed:24608264).
(Microbial infection) In case of infection by influenza virus A (IVA), is involved in viral replication (PubMed:21900157).

Biological Process

Biological Process negative regulation of protein kinase activityManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process RNA transportManual Assertion Based On ExperimentTAS:UniProtKB
Biological Process tRNA splicing, via endonucleolytic cleavage and ligationManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Nucleus
Cytoplasm, cytosol
Cytoplasm, perinuclear region
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
May localize at the centrosome during mitosis (PubMed:15147888).
Shuttles between the cytosol and the nucleus: enters into the nucleus in case of active transcription while it accumulates in cytosol when transcription level is low (PubMed:24608264).
Nucleus
Cytoplasm
(Microbial infection) Following influenza A virus (IAV) infection, included in influenza A virions via its association with packaged viral ribonucleoproteins (vRNP) in the nucleus and cytoplasm (PubMed:21900157, PubMed:26864902).

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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