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Rabbit Anti-RYBP Recombinant Antibody (D8J7W) (CBMAB-CP2327-LY)

The product is antibody recognizes RYBP. The antibody D8J7W immunoassay techniques such as: WB,IP.
See all RYBP antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat, Monkey
Clone
D8J7W
Antibody Isotype
IgG
Application
WB, IP

Basic Information

Immunogen
Monoclonal antibody is produced by immunizing animals with recombinant protein specific to the amino terminus of human RYBP protein.
Specificity
Human, Mouse, Rat, Monkey
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
RING1 And YY1 Binding Protein
Introduction
RYBP (RING1 And YY1 Binding Protein) is a Protein Coding gene. Among its related pathways are E2F transcription factor network and Chromatin Regulation / Acetylation. Gene Ontology (GO) annotations related to this gene include transcription corepressor activity. An important paralog of this gene is YAF2.
Entrez Gene ID
Human23429
Mouse56353
Rat312603
Monkey694390
UniProt ID
HumanQ8N488
MouseQ8CCI5
MonkeyI0FKU8
Alternative Names
RING1 And YY1 Binding Protein; Death Effector Domain-Associated Factor; Apoptin-Associating Protein 1; YY1 And E4TF1 Associated Factor 1; Ring1 Interactor RYBP; DED-Associated Factor; APAP-1;
Function
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1-like complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:25519132).
Component of a PRC1-like complex that mediates monoubiquitination of histone H2A 'Lys-119' on the X chromosome and is required for normal silencing of one copy of the X chromosome in XX females. May stimulate ubiquitination of histone H2A 'Lys-119' by recruiting the complex to target sites (By similarity).
Inhibits ubiquitination and subsequent degradation of TP53, and thereby plays a role in regulating transcription of TP53 target genes (PubMed:19098711).
May also regulate the ubiquitin-mediated proteasomal degradation of other proteins like FANK1 to regulate apoptosis (PubMed:14765135, PubMed:27060496).
May be implicated in the regulation of the transcription as a repressor of the transcriptional activity of E4TF1 (PubMed:11953439).
May bind to DNA (By similarity).
May play a role in the repression of tumor growth and metastasis in breast cancer by down-regulating SRRM3 (PubMed:27748911).
Biological Process
Biological Process apoptotic processIEA:UniProtKB-KW
Biological Process histone H2A monoubiquitinationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of proteasomal ubiquitin-dependent protein catabolic processManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Nucleus
Cytoplasm
Nucleus, nucleoplasm
Primarily found in the nucleus. Detected in a punctate pattern likely to represent Polycomb group (PcG) bodies (By similarity).
PTM
Monoubiquitinated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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