RYBP

RYBP (RING1 And YY1 Binding Protein) is a Protein Coding gene. Among its related pathways are E2F transcription factor network and Chromatin Regulation / Acetylation. Gene Ontology (GO) annotations related to this gene include transcription corepressor activity. An important paralog of this gene is YAF2.
Full Name
RING1 And YY1 Binding Protein
Function
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1-like complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:25519132).
Component of a PRC1-like complex that mediates monoubiquitination of histone H2A 'Lys-119' on the X chromosome and is required for normal silencing of one copy of the X chromosome in XX females. May stimulate ubiquitination of histone H2A 'Lys-119' by recruiting the complex to target sites (By similarity).
Inhibits ubiquitination and subsequent degradation of TP53, and thereby plays a role in regulating transcription of TP53 target genes (PubMed:19098711).
May also regulate the ubiquitin-mediated proteasomal degradation of other proteins like FANK1 to regulate apoptosis (PubMed:14765135, PubMed:27060496).
May be implicated in the regulation of the transcription as a repressor of the transcriptional activity of E4TF1 (PubMed:11953439).
May bind to DNA (By similarity).
May play a role in the repression of tumor growth and metastasis in breast cancer by down-regulating SRRM3 (PubMed:27748911).
Biological Process
Biological Process apoptotic processIEA:UniProtKB-KW
Biological Process histone H2A monoubiquitinationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of proteasomal ubiquitin-dependent protein catabolic processManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Nucleus
Cytoplasm
Nucleus, nucleoplasm
Primarily found in the nucleus. Detected in a punctate pattern likely to represent Polycomb group (PcG) bodies (By similarity).
PTM
Monoubiquitinated.
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Anti-RYBP antibodies

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Rabbit Anti-RYBP Recombinant Antibody (D8J7W) (CBMAB-CP2327-LY)

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Target: RYBP
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey
Clone: D8J7W
Application*: WB, IP
Datasheet SDS

Mouse Anti-RYBP Recombinant Antibody (A-1) (CBMAB-R3988-CN)

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Target: RYBP
Host: Mouse
Specificity: Human
Clone: A-1
Application*: WB, IP, IF, P, E
Datasheet SDS

Mouse Anti-RYBP Recombinant Antibody (4E10) (CBMAB-R3985-CN)

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Target: RYBP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 4E10
Application*: WB, IF
Datasheet SDS

Mouse Anti-RYBP Recombinant Antibody (2H9) (CBMAB-R3984-CN)

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Target: RYBP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2H9
Application*: WB, F
Datasheet SDS

Mouse Anti-RYBP Recombinant Antibody (2F6) (CBMAB-R3983-CN)

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Target: RYBP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2F6
Application*: WB
Datasheet SDS

Mouse Anti-RYBP Recombinant Antibody (2D4) (CBMAB-R3982-CN)

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Target: RYBP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2D4
Application*: WB
Datasheet SDS

Mouse Anti-RYBP Recombinant Antibody (2B4) (CBMAB-R3981-CN)

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Target: RYBP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Dog, Monkey
Clone: 2B4
Application*: WB
Datasheet SDS

Mouse Anti-RYBP Recombinant Antibody (1F4) (CBMAB-R3980-CN)

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Target: RYBP
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1F4
Application*: E, IP, WB
Datasheet SDS

Mouse Anti-RYBP Recombinant Antibody (1B6) (CBMAB-R3979-CN)

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Target: RYBP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1B6
Application*: WB, F
Datasheet SDS

Mouse Anti-RYBP Recombinant Antibody (1B2) (CBMAB-R3978-CN)

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Target: RYBP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1B2
Application*: WB, IH, IF, P
Datasheet SDS

Human Recombinant RYBP protein, GST Tag (V2LY-0526-LY6634)

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Target: RYBP
Expressed Host: Baculovirus-Insect Cells
Sequence: Amino Acid: 1-228
Tag: GST Tag
Datasheet SDS
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Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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