Mouse Anti-S100A1 Recombinant Antibody (2C8B8, 2C8E8,3C8D8) (CBMAB-AO937LY)

Name: Mouse Anti-S100A1 Recombinant Antibody (2C8B8, 2C8E8,3C8D8)
SKU: CBMAB-AO937LY
Rating: 5 (1 reviews)

See all S100A1 antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

2C8B8, 2C8E8,3C8D8

Application

WB, IHC

Immunogen

Purified recombinant fragment of S100A1 expressed in E. coli.

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Ascites

Preservative

0.03% sodium azide

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

S100 Calcium Binding Protein A1

Introduction

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-induced Ca2+ release, inhibition of microtubule assembly, and inhibition of protein kinase C-mediated phosphorylation. Reduced expression of this protein has been implicated in cardiomyopathies. [provided by RefSeq, Jul 2008]

Entrez Gene ID

6271

UniProt ID

P23297

Alternative Names

S-100A1; S100-A1; S100A1; Protein S100-A1; S100 calcium-binding protein A1; S-100 protein subunit alpha; S-100 protein alpha chain

Function

Small calcium binding protein that plays important roles in several biological processes such as Ca2+ homeostasis, chondrocyte biology and cardiomyocyte regulation (PubMed:12804600).
In response to an increase in intracellular Ca2+ levels, binds calcium which triggers conformational changes (PubMed:23351007).
These changes allow interactions with specific target proteins and modulate their activity (PubMed:22399290).
Regulates a network in cardiomyocytes controlling sarcoplasmic reticulum Ca2+ cycling and mitochondrial function through interaction with the ryanodine receptors RYR1 and RYR2, sarcoplasmic reticulum Ca2+-ATPase/ATP2A2 and mitochondrial F1-ATPase (PubMed:12804600).
Facilitates diastolic Ca2+ dissociation and myofilament mechanics in order to improve relaxation during diastole (PubMed:11717446).

Biological Process

Biological Process intracellular signal transduction1 PublicationNAS:UniProtKB
Biological Process positive regulation of nitric-oxide synthase activityManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process positive regulation of sprouting angiogenesisManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process regulation of heart contraction1 PublicationNAS:UniProtKB
Biological Process substantia nigra developmentManual Assertion Based On ExperimentHEP:UniProtKB

Cellular Location

Cytoplasm
Sarcoplasmic reticulum
Mitochondrion

PTM

Glutathionylated; glutathionylation increases affinity to calcium about 10-fold.

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Mouse Anti-S100A1 Recombinant Antibody (2C8B8, 2C8E8,3C8D8)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Mouse Anti-S100A1 Recombinant Antibody (SPM354) (CAT#: CBMAB-S0181-CQ)

Rabbit Anti-S100A1 Recombinant Antibody (CBFYC-3087) (CAT#: CBMAB-C3164-FY)

Mouse Anti-S100A1 Recombinant Antibody (S100A1/1942) (CAT#: CBMAB-S6506-CQ)

Mouse Anti-S100A1 Recombinant Antibody (CBXS-0067) (CAT#: CBMAB-S3067-CQ)

Rabbit Anti-S100A1 Recombinant Antibody (CBXS-4285) (CAT#: CBMAB-S1531-CQ)

Rabbit Anti-S100A1 Recombinant Antibody (S100A1/1706R) (CAT#: CBMAB-S0347-CQ)

Mouse Anti-S100A1 Recombinant Antibody (CBXS-4982) (CAT#: CBMAB-S2204-CQ)

Mouse Anti-S100A1 Recombinant Antibody (CBXS-5234) (CAT#: CBMAB-S2449-CQ)

Rabbit Anti-S100A1 Recombinant Antibody (CBXS-1527) (CAT#: CBMAB-S4378-CQ)

Mouse Anti-S100A1 Recombinant Antibody (CBT2769) (CAT#: V2LY-0625-LY2118)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry