S100A1

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-induced Ca2+ release, inhibition of microtubule assembly, and inhibition of protein kinase C-mediated phosphorylation. Reduced expression of this protein has been implicated in cardiomyopathies. [provided by RefSeq, Jul 2008]
Full Name
S100 Calcium Binding Protein A1
Function
Small calcium binding protein that plays important roles in several biological processes such as Ca2+ homeostasis, chondrocyte biology and cardiomyocyte regulation (PubMed:12804600).
In response to an increase in intracellular Ca2+ levels, binds calcium which triggers conformational changes (PubMed:23351007).
These changes allow interactions with specific target proteins and modulate their activity (PubMed:22399290).
Regulates a network in cardiomyocytes controlling sarcoplasmic reticulum Ca2+ cycling and mitochondrial function through interaction with the ryanodine receptors RYR1 and RYR2, sarcoplasmic reticulum Ca2+-ATPase/ATP2A2 and mitochondrial F1-ATPase (PubMed:12804600).
Facilitates diastolic Ca2+ dissociation and myofilament mechanics in order to improve relaxation during diastole (PubMed:11717446).
Biological Process
Biological Process intracellular signal transduction1 PublicationNAS:UniProtKB
Biological Process positive regulation of nitric-oxide synthase activityManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process positive regulation of sprouting angiogenesisManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process regulation of heart contraction1 PublicationNAS:UniProtKB
Biological Process substantia nigra developmentManual Assertion Based On ExperimentHEP:UniProtKB
Cellular Location
Cytoplasm
Sarcoplasmic reticulum
Mitochondrion
PTM
Glutathionylated; glutathionylation increases affinity to calcium about 10-fold.
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Anti-S100A1 antibodies

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Mouse Anti-S100A1 Recombinant Antibody (2C8B8, 2C8E8,3C8D8) (CBMAB-AO937LY)

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Target: S100A1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2C8B8, 2C8E8,3C8D8
Application*: WB, IHC
Datasheet SDS

Mouse Anti-S100A1 Recombinant Antibody (1D5) (CBMAB-A7851-LY)

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Target: S100A1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1D5
Application*: WB, E
Datasheet SDS

Mouse Anti-S100A1 Recombinant Antibody (S100A1/1942) (CBMAB-S6506-CQ)

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Target: S100A1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: S100A1/1942
Application*: IF, P
Datasheet SDS

Mouse Anti-S100A1 Recombinant Antibody (S100 217) (CBMAB-S6505-CQ)

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Target: S100A1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse, Rat, Cattle, Human, Monkey
Clone: S100 217
Application*: P, C, F, IF
Datasheet SDS

Mouse Anti-S100A1 Recombinant Antibody (S1/61) (CBMAB-S6504-CQ)

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Target: S100A1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: S1/61
Application*: P, IF
Datasheet SDS

Mouse Anti-S100A1 Recombinant Antibody (CBXS-2434) (CBMAB-S5191-CQ)

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Target: S100A1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-2434
Application*: E, IH, WB
Datasheet SDS

Rabbit Anti-S100A1 Recombinant Antibody (CBXS-1527) (CBMAB-S4378-CQ)

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Target: S100A1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Rat, Human
Clone: CBXS-1527
Application*: WB, IP, P, F
Datasheet SDS

Rabbit Anti-S100A1 Recombinant Antibody (CBXS-1133) (CBMAB-S4017-CQ)

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Target: S100A1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBXS-1133
Application*: EC
Datasheet SDS

Rabbit Anti-S100A1 Recombinant Antibody (CBXS-1055) (CBMAB-S3946-CQ)

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Target: S100A1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBXS-1055
Application*: P
Datasheet SDS

Mouse Anti-S100A1 Recombinant Antibody (CBXS-0067) (CBMAB-S3067-CQ)

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Target: S100A1
Host: Mouse
Specificity: Rat
Clone: CBXS-0067
Application*: WB, IC, P, C, E
Datasheet SDS

Mouse Anti-S100A1 Recombinant Antibody (CBXS-0066) (CBMAB-S3066-CQ)

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Target: S100A1
Host: Mouse
Specificity: Human
Clone: CBXS-0066
Application*: WB, IC, P, C, E
Datasheet SDS

Rabbit Anti-S100A1 Recombinant Antibody (CBXS-5480) (CBMAB-S2690-CQ)

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Target: S100A1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBXS-5480
Application*: F, IF, IP, WB
Datasheet SDS

Mouse Anti-S100A1 Recombinant Antibody (CBXS-5274) (CBMAB-S2488-CQ)

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Target: S100A1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-5274
Application*: E, IF, IH, P, WB
Datasheet SDS

Mouse Anti-S100A1 Recombinant Antibody (CBXS-5234) (CBMAB-S2449-CQ)

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Target: S100A1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-5234
Application*: WB, E
Datasheet SDS

Mouse Anti-S100A1 Recombinant Antibody (CBXS-5232) (CBMAB-S2447-CQ)

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Target: S100A1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-5232
Application*: C, P, WB
Datasheet SDS

Mouse Anti-S100A1 Recombinant Antibody (CBXS-4982) (CBMAB-S2204-CQ)

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Target: S100A1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse
Clone: CBXS-4982
Application*: E, IF, P, WB
Datasheet SDS

Mouse Anti-S100A1 Recombinant Antibody (CBXS-4463) (CBMAB-S1705-CQ)

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Target: S100A1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4463
Application*: WB, E, IH, P
Datasheet SDS

Rabbit Anti-S100A1 Recombinant Antibody (CBXS-4285) (CBMAB-S1531-CQ)

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Target: S100A1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBXS-4285
Application*: P
Datasheet SDS

Mouse Anti-S100A1 Recombinant Antibody (CBXS-3741) (CBMAB-S1016-CQ)

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Target: S100A1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXS-3741
Application*: P, F
Datasheet SDS

Rabbit Anti-S100A1 Recombinant Antibody (CBXS-3722) (CBMAB-S0997-CQ)

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Target: S100A1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBXS-3722
Application*: E, ED
Datasheet SDS

Mouse Anti-S100A1 Recombinant Antibody (CBXS-5860) (CBMAB-S0713-CQ)

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Target: S100A1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-5860
Application*: P, WB
Datasheet SDS

Rabbit Anti-S100A1 Recombinant Antibody (S100A1/1706R) (CBMAB-S0347-CQ)

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Target: S100A1
Host: Rabbit
Antibody Isotype: IgG, κ
Specificity: Human, Mouse, Rat, Cattle
Clone: S100A1/1706R
Application*: WB, F, IF, P, MC
Datasheet SDS

Mouse Anti-S100A1 Recombinant Antibody (S100A1/1012) (CBMAB-S0346-CQ)

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Target: S100A1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat, Cattle
Clone: S100A1/1012
Application*: WB, F, P, IF
Datasheet SDS

Mouse Anti-S100A1 Recombinant Antibody (SPM354) (CBMAB-S0181-CQ)

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Target: S100A1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat, Cattle
Clone: SPM354
Application*: WB, F, E, IF, IP, P, C, MC
Datasheet SDS

Rabbit Anti-S100A1 Recombinant Antibody (CBFYC-3087) (CBMAB-C3164-FY)

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Target: S100A1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBFYC-3087
Application*: E
Datasheet SDS

Mouse Anti-S100A1 Recombinant Antibody (6G1) (CBMAB-A4724-YC)

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Target: S100A1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 6G1
Application*: E, WB
Datasheet SDS

Mouse Anti-S100A1 Recombinant Antibody (CBT1116) (V2LY-0625-LY3022)

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Target: S100A1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBT1116
Application*: WB, P, IF, E
Datasheet SDS

Mouse Anti-S100A1 Recombinant Antibody (CBT2769) (V2LY-0625-LY2118)

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Target: S100A1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT2769
Application*: IH
Datasheet SDS

Rabbit Anti-S100A1 Recombinant Antibody (BA0180) (CBMAB-0779CQ)

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Target: S100A1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Human
Clone: BA0180
Application*: F, C, P, IP, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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