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S100A1

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-induced Ca2+ release, inhibition of microtubule assembly, and inhibition of protein kinase C-mediated phosphorylation. Reduced expression of this protein has been implicated in cardiomyopathies. [provided by RefSeq, Jul 2008]

Full Name

S100 Calcium Binding Protein A1

Function

Small calcium binding protein that plays important roles in several biological processes such as Ca2+ homeostasis, chondrocyte biology and cardiomyocyte regulation (PubMed:12804600).
In response to an increase in intracellular Ca2+ levels, binds calcium which triggers conformational changes (PubMed:23351007).
These changes allow interactions with specific target proteins and modulate their activity (PubMed:22399290).
Regulates a network in cardiomyocytes controlling sarcoplasmic reticulum Ca2+ cycling and mitochondrial function through interaction with the ryanodine receptors RYR1 and RYR2, sarcoplasmic reticulum Ca2+-ATPase/ATP2A2 and mitochondrial F1-ATPase (PubMed:12804600).
Facilitates diastolic Ca2+ dissociation and myofilament mechanics in order to improve relaxation during diastole (PubMed:11717446).

Biological Process

Biological Process intracellular signal transduction1 PublicationNAS:UniProtKB
Biological Process positive regulation of nitric-oxide synthase activityManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process positive regulation of sprouting angiogenesisManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process regulation of heart contraction1 PublicationNAS:UniProtKB
Biological Process substantia nigra developmentManual Assertion Based On ExperimentHEP:UniProtKB

Cellular Location

Cytoplasm
Sarcoplasmic reticulum
Mitochondrion

PTM

Glutathionylated; glutathionylation increases affinity to calcium about 10-fold.

Anti-S100A1 antibodies

Rabbit Anti-S100A1 Recombinant Antibody (BA0180) (CBMAB-0779CQ)

SDS

Target: S100A1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Mouse, Human

Clone: BA0180

Application*: F, C, P, IP, WB

Mouse Anti-S100A1 Recombinant Antibody (S100A1/1942) (CBMAB-S6506-CQ)

SDS

Target: S100A1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: S100A1/1942

Application*: IF, P

Mouse Anti-S100A1 Recombinant Antibody (S100 217) (CBMAB-S6505-CQ)

SDS

Target: S100A1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Mouse, Rat, Cattle, Human, Monkey

Clone: S100 217

Application*: P, C, F, IF

Mouse Anti-S100A1 Recombinant Antibody (S1/61) (CBMAB-S6504-CQ)

SDS

Target: S100A1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: S1/61

Application*: P, IF

Mouse Anti-S100A1 Recombinant Antibody (CBXS-2434) (CBMAB-S5191-CQ)

SDS

Target: S100A1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXS-2434

Application*: E, IH, WB

Rabbit Anti-S100A1 Recombinant Antibody (CBXS-1527) (CBMAB-S4378-CQ)

SDS

Target: S100A1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Mouse, Rat, Human

Clone: CBXS-1527

Application*: WB, IP, P, F

Rabbit Anti-S100A1 Recombinant Antibody (CBXS-1133) (CBMAB-S4017-CQ)

SDS

Target: S100A1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Mouse

Clone: CBXS-1133

Application*: EC

Rabbit Anti-S100A1 Recombinant Antibody (CBXS-1055) (CBMAB-S3946-CQ)

SDS

Target: S100A1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Mouse

Clone: CBXS-1055

Application*: P

Mouse Anti-S100A1 Recombinant Antibody (CBXS-0067) (CBMAB-S3067-CQ)

SDS

Target: S100A1

Host: Mouse

Specificity: Rat

Clone: CBXS-0067

Application*: WB, IC, P, C, E

Mouse Anti-S100A1 Recombinant Antibody (CBXS-0066) (CBMAB-S3066-CQ)

SDS

Target: S100A1

Host: Mouse

Specificity: Human

Clone: CBXS-0066

Application*: WB, IC, P, C, E

Rabbit Anti-S100A1 Recombinant Antibody (CBXS-5480) (CBMAB-S2690-CQ)

SDS

Target: S100A1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: CBXS-5480

Application*: F, IF, IP, WB

Mouse Anti-S100A1 Recombinant Antibody (CBXS-5274) (CBMAB-S2488-CQ)

SDS

Target: S100A1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXS-5274

Application*: E, IF, IH, P, WB

Mouse Anti-S100A1 Recombinant Antibody (CBXS-5234) (CBMAB-S2449-CQ)

SDS

Target: S100A1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXS-5234

Application*: WB, E

Mouse Anti-S100A1 Recombinant Antibody (CBXS-5232) (CBMAB-S2447-CQ)

SDS

Target: S100A1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXS-5232

Application*: C, P, WB

Mouse Anti-S100A1 Recombinant Antibody (CBXS-4982) (CBMAB-S2204-CQ)

SDS

Target: S100A1

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human, Mouse

Clone: CBXS-4982

Application*: E, IF, P, WB

Mouse Anti-S100A1 Recombinant Antibody (CBXS-4463) (CBMAB-S1705-CQ)

SDS

Target: S100A1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXS-4463

Application*: WB, E, IH, P

Rabbit Anti-S100A1 Recombinant Antibody (CBXS-4285) (CBMAB-S1531-CQ)

SDS

Target: S100A1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Mouse

Clone: CBXS-4285

Application*: P

Mouse Anti-S100A1 Recombinant Antibody (CBXS-3741) (CBMAB-S1016-CQ)

SDS

Target: S100A1

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBXS-3741

Application*: P, F

Rabbit Anti-S100A1 Recombinant Antibody (CBXS-3722) (CBMAB-S0997-CQ)

SDS

Target: S100A1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Mouse

Clone: CBXS-3722

Application*: E, ED

Mouse Anti-S100A1 Recombinant Antibody (CBXS-5860) (CBMAB-S0713-CQ)

SDS

Target: S100A1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXS-5860

Application*: P, WB

Rabbit Anti-S100A1 Recombinant Antibody (S100A1/1706R) (CBMAB-S0347-CQ)

SDS

Target: S100A1

Host: Rabbit

Antibody Isotype: IgG, κ

Specificity: Human, Mouse, Rat, Cattle

Clone: S100A1/1706R

Application*: WB, F, IF, P, MC

Mouse Anti-S100A1 Recombinant Antibody (S100A1/1012) (CBMAB-S0346-CQ)

SDS

Target: S100A1

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human, Mouse, Rat, Cattle

Clone: S100A1/1012

Application*: WB, F, P, IF

Mouse Anti-S100A1 Recombinant Antibody (SPM354) (CBMAB-S0181-CQ)

SDS

Target: S100A1

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human, Mouse, Rat, Cattle

Clone: SPM354

Application*: WB, F, E, IF, IP, P, C, MC

Rabbit Anti-S100A1 Recombinant Antibody (CBFYC-3087) (CBMAB-C3164-FY)

SDS

Target: S100A1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Mouse

Clone: CBFYC-3087

Application*: E

Mouse Anti-S100A1 Recombinant Antibody (2C8B8, 2C8E8,3C8D8) (CBMAB-AO937LY)

SDS

Target: S100A1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 2C8B8, 2C8E8,3C8D8

Application*: WB, IHC

Mouse Anti-S100A1 Recombinant Antibody (1D5) (CBMAB-A7851-LY)

SDS

Target: S100A1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 1D5

Application*: WB, E

Mouse Anti-S100A1 Recombinant Antibody (6G1) (CBMAB-A4724-YC)

SDS

Target: S100A1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 6G1

Application*: E, WB

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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