Human Recombinant S100A1 protein (V2LY-0526-LY6637)

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Datasheet
SDS
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Basic Information

Expressed Host
E. coli
Protein Species
Human
Protein Construction
This product is Human Recombinant S100A1 protein consist of Amino Acid: 1-94 and predicts a molecular mass of 10.5 kDa.
Molecule Mass
10.5 kDa
Sequence
Amino Acid: 1-94
Species
Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity
>97% as determined by SDS-PAGE
Endotoxin
Please contact us for more information.
Format
Lyophilized
Reconstitution
Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.
Buffer
Lyophilized from sterile PBS
Preservative
None
Storage
Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
More Infomation

Target

Full Name
S100 Calcium Binding Protein A1
Function
Small calcium binding protein that plays important roles in several biological processes such as Ca2+ homeostasis, chondrocyte biology and cardiomyocyte regulation (PubMed:12804600).
In response to an increase in intracellular Ca2+ levels, binds calcium which triggers conformational changes (PubMed:23351007).
These changes allow interactions with specific target proteins and modulate their activity (PubMed:22399290).
Regulates a network in cardiomyocytes controlling sarcoplasmic reticulum Ca2+ cycling and mitochondrial function through interaction with the ryanodine receptors RYR1 and RYR2, sarcoplasmic reticulum Ca2+-ATPase/ATP2A2 and mitochondrial F1-ATPase (PubMed:12804600).
Facilitates diastolic Ca2+ dissociation and myofilament mechanics in order to improve relaxation during diastole (PubMed:11717446).
Biological Process
Biological Process intracellular signal transduction1 PublicationNAS:UniProtKB
Biological Process positive regulation of nitric-oxide synthase activityManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process positive regulation of sprouting angiogenesisManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process regulation of heart contraction1 PublicationNAS:UniProtKB
Biological Process substantia nigra developmentManual Assertion Based On ExperimentHEP:UniProtKB
Cellular Location
Cytoplasm
Sarcoplasmic reticulum
Mitochondrion
PTM
Glutathionylated; glutathionylation increases affinity to calcium about 10-fold.
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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Rat S100a1 ELISA Kit (CAT#: V2LY-0626-LY2551)

Human Recombinant S100A1 protein, hFc Tag (CAT#: V2LY-0526-LY6638)

Mouse Recombinant S100A1 protein, His Tag (CAT#: V2LY-0526-LY8852)

Related Products

Mouse Anti-S100A1 Recombinant Antibody (S100 217) (CAT#: CBMAB-S6505-CQ)

Mouse Anti-S100A1 Recombinant Antibody (CBXS-4463) (CAT#: CBMAB-S1705-CQ)

Mouse Anti-S100A1 Recombinant Antibody (CBT1116) (CAT#: V2LY-0625-LY3022)

Rabbit Anti-S100A1 Recombinant Antibody (CBXS-1133) (CAT#: CBMAB-S4017-CQ)

Rat S100a1 ELISA Kit (CAT#: V2LY-0626-LY2551)

Mouse Anti-S100A1 Recombinant Antibody (CBXS-0066) (CAT#: CBMAB-S3066-CQ)

Mouse Anti-S100A1 Recombinant Antibody (1D5) (CAT#: CBMAB-A7851-LY)

Rabbit Anti-S100A1 Recombinant Antibody (CBXS-5480) (CAT#: CBMAB-S2690-CQ)

Rabbit Anti-S100A1 Recombinant Antibody (CBXS-1527) (CAT#: CBMAB-S4378-CQ)

Rabbit Anti-S100A1 Recombinant Antibody (CBXS-1055) (CAT#: CBMAB-S3946-CQ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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