Mouse Anti-S100A9 Recombinant Antibody (A1177) (CBMAB-AP12274LY)

Mouse

Human, Mouse, Rat

A1177

IgG

WB

A synthetic peptide corresponding to residues in Human MRP14

Human, Mouse, Rat

IgG

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Liquid

Affinity purity

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Protein S100-A9, Calgranulin-B, Calprotectin L1H subunit, Leukocyte L1 complex heavy chain, Migration inhibitory factor-related protein 14, MRP-14, p14, S100 calcium-binding protein A9, S100A9, CAGB, CFAG, MRP14, MRP8+MRP14

AP0477M

Biological Process activation of cysteine-type endopeptidase activity involved in apoptotic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process antimicrobial humoral immune response mediated by antimicrobial peptideManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process apoptotic processIEA:UniProtKB-KW
Biological Process astrocyte developmentManual Assertion Based On ExperimentIBA:GO_Central
Biological Process autocrine signalingManual Assertion Based On ExperimentIBA:GO_Central
Biological Process autophagyManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process cell-cell signalingManual Assertion Based On ExperimentTAS:ProtInc
Biological Process chronic inflammatory responseManual Assertion Based On ExperimentIBA:GO_Central
Biological Process defense response to bacteriumManual Assertion Based On ExperimentTAS:UniProtKB
Biological Process defense response to fungusManual Assertion Based On ExperimentTAS:UniProtKB
Biological Process inflammatory responseManual Assertion Based On ExperimentTAS:ProtInc
Biological Process innate immune responseIEA:UniProtKB-KW
Biological Process leukocyte migration involved in inflammatory responseManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process modulation of process of another organismManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process neutrophil aggregationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process neutrophil chemotaxisManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process peptidyl-cysteine S-nitrosylationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process peptidyl-cysteine S-trans-nitrosylationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of cell growthManual Assertion Based On ExperimentTAS:UniProtKB
Biological Process positive regulation of inflammatory responseManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of intrinsic apoptotic signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of neuron projection developmentISS:ARUK-UCL
Biological Process positive regulation of NF-kappaB transcription factor activityManual Assertion Based On ExperimentTAS:UniProtKB
Biological Process regulation of cytoskeleton organizationManual Assertion Based On ExperimentTAS:UniProtKB
Biological Process regulation of integrin biosynthetic processManual Assertion Based On ExperimentIBA:GO_Central
Biological Process response to lipopolysaccharideManual Assertion Based On ExperimentIBA:GO_Central
Biological Process sequestering of zinc ionManual Assertion Based On ExperimentTAS:UniProtKB

Secreted
Cytoplasm
Cytoplasm, cytoskeleton
Cell membrane
Predominantly localized in the cytoplasm. Upon elevation of the intracellular calcium level, translocated from the cytoplasm to the cytoskeleton and the cell membrane (PubMed:18786929).
Upon neutrophil activation or endothelial adhesion of monocytes, is secreted via a microtubule-mediated, alternative pathway (PubMed:15598812).

Phosphorylated. Phosphorylation inhibits activation of tubulin polymerization.
S-nitrosylation of Cys-3 is implicated in LDL(ox)-induced S-nitrosylation of GAPDH at 'Cys-247' through a transnitrosylase mechanism involving a iNOS-S100A8/9 complex (PubMed:25417112).
Methylation at His-105 by METTL9 reduces zinc-binding without affecting heterodimerization with S100A8.