Mouse Anti-S100B Recombinant Antibody (CBXS-4300) (CBMAB-S1545-CQ)

Name: Mouse Anti-S100B Recombinant Antibody (CBXS-4300)
SKU: CBMAB-S1545-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBXS-4300

Application

Specificity

Mouse

Antibody Isotype

IgM, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

0.09% sodium azide

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

S100 Calcium Binding Protein B

Introduction

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21; however, this gene is located at 21q22.3. This protein may function in Neurite extension, proliferation of melanoma cells, stimulation of Ca2+ fluxes, inhibition of PKC-mediated phosphorylation, astrocytosis and axonal proliferation, and inhibition of microtubule assembly. Chromosomal rearrangements and altered expression of this gene have been implicated in several neurological, neoplastic, and other types of diseases, including Alzheimer's disease, Down's syndrome, epilepsy, amyotrophic lateral sclerosis, melanoma, and type I diabetes.

Entrez Gene ID

20203

UniProt ID

P50114

Alternative Names

AI850290; Bpb

Function

Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization. May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity.

Biological Process

Biological Process axonogenesisManual Assertion Based On ExperimentTAS:ProtInc
Biological Process central nervous system developmentManual Assertion Based On ExperimentTAS:ProtInc
Biological Process learning or memoryISS:UniProtKB
Biological Process memoryIEA:Ensembl
Biological Process positive regulation of cell population proliferationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of I-kappaB kinase/NF-kappaB signalingManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of neuronal synaptic plasticityIEA:Ensembl

Cellular Location

Cytoplasm
Nucleus

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Antibody Pairs

S100B Matched Antibody Pair (1034) (CAT#: APMAB-1034LY)

S100B Matched Antibody Pair (1035) (CAT#: APMAB-1035LY)

S100B Matched Antibody Pair (1036) (CAT#: APMAB-1036LY)

S100B Matched Antibody Pair (1037) (CAT#: APMAB-1037LY)

Related Products

Rabbit Anti-S100B Recombinant Antibody (RM304) (CAT#: CBMAB-BR437LY)

S100B Matched Antibody Pair (1037) (CAT#: APMAB-1037LY)

Mouse Anti-S100B Recombinant Antibody (G4B9) (CAT#: CBMAB-S6342-CQ)

Mouse Anti-S100B Recombinant Antibody (1A19) (CAT#: CBMAB-A7876-LY)

Mouse Anti-S100B Recombinant Antibody (CBXS-5770) (CAT#: CBMAB-S0629-CQ)

Mouse Anti-S100 Alpha/Beta Recombinant Antibody (3B10) (CAT#: CBMAB-0791CQ)

S100B Matched Antibody Pair (1034) (CAT#: APMAB-1034LY)

Mouse Anti-S100B Recombinant Antibody (SPM354) (CAT#: CBMAB-S0047-CQ)

Mouse Anti-S100B Recombinant Antibody (CBXS-2665) (CAT#: CBMAB-S5417-CQ)

Mouse Anti-S100B Recombinant Antibody (CBXS-3139) (CAT#: CBMAB-S5881-CQ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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