Rabbit Anti-SAE1 Recombinant Antibody (CBXS-1402) (CBMAB-S4260-CQ)

Name: Rabbit Anti-SAE1 Recombinant Antibody (CBXS-1402)
SKU: CBMAB-S4260-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Rabbit

Clone

CBXS-1402

Application

WB, IP, FC, IF

Specificity

Rat, Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration

1.183 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

SUMO1 Activating Enzyme Subunit 1

Introduction

Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. SAE1 and UBA2 (MIM 613295) form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins (Okuma et al., 1999 [PubMed 9920803]).

Entrez Gene ID

Human	10055
Rat	308384

UniProt ID

Human	Q9UBE0
Rat	Q6AXQ0

Alternative Names

SUMO1 Activating Enzyme Subunit 1; Ubiquitin-Like 1-Activating Enzyme E1A; UBLE1A; AOS1; SUA1; Ubiquitin-Like Protein SUMO-1 Activating Enzyme; SUMO-1 Activating Enzyme E1 N Subunit;

Function

The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2.

Biological Process

Biological Process positive regulation of protein sumoylationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of protein targeting to mitochondrionManual Assertion Based On ExperimentHMP:ParkinsonsUK-UCL
Biological Process protein modification by small protein conjugationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process protein sumoylationManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Nucleus

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Antibody Pairs

SAE1 Matched Antibody Pair (1038) (CAT#: APMAB-1038LY)

SAE1 Matched Antibody Pair (1039) (CAT#: APMAB-1039LY)

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Mouse Anti-SAE1 Recombinant Antibody (CBXS-5796) (CAT#: CBMAB-S0654-CQ)

SAE1 Matched Antibody Pair (1038) (CAT#: APMAB-1038LY)

Mouse Anti-SAE1 Recombinant Antibody (CBXS-4312) (CAT#: CBMAB-S1557-CQ)

SAE1 Matched Antibody Pair (1039) (CAT#: APMAB-1039LY)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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