SAE1
Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. SAE1 and UBA2 (MIM 613295) form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins (Okuma et al., 1999 [PubMed 9920803]).[supplied by OMIM, Mar 2010]
Full Name
SUMO1 Activating Enzyme Subunit 1
Function
The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2.
Biological Process
Biological Process positive regulation of protein sumoylationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of protein targeting to mitochondrionManual Assertion Based On ExperimentHMP:ParkinsonsUK-UCL
Biological Process protein modification by small protein conjugationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process protein sumoylationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of protein targeting to mitochondrionManual Assertion Based On ExperimentHMP:ParkinsonsUK-UCL
Biological Process protein modification by small protein conjugationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process protein sumoylationManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Nucleus
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Anti-SAE1 antibodies
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CompareTarget: SAE1
Host: Mouse
Antibody Isotype: IgG1, λ
Specificity: Human
Clone: 1G4-1G5
Application*: WB, E
Target: SAE1
Host: Mouse
Specificity: Human
Clone: CBXS-3471
Application*: DB, WB
Target: SAE1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Rat, Human
Clone: CBXS-1402
Application*: WB, IP, F, IF
Target: SAE1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Human
Clone: CBXS-1401
Application*: WB, IF
Target: SAE1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-1072
Application*: E
Target: SAE1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4802
Application*: P, WB
Target: SAE1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-4793
Application*: WB
Target: SAE1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4386
Application*: WB
Target: SAE1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4312
Application*: DB, IC, IF, WB
Target: SAE1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-4192
Application*: IF, P, WB
Target: SAE1
Host: Mouse
Antibody Isotype: IgG1, λ
Specificity: Human
Clone: CBXS-4172
Application*: WB, E, IH, IF
Target: SAE1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-5806
Application*: P, WB
Target: SAE1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-5796
Application*: WB, IH
Target: SAE1
Expressed Host: Baculovirus-Insect Cells
Sequence: Amino Acid: Full Length
Tag: His & GST Tag
Target: SAE1
Expressed Host: Baculovirus-Insect Cells
Sequence: Amino Acid: 1-346
Target: SAE1
Expressed Host: Baculovirus-Insect Cells
Sequence: Amino Acid: 1-346
Tag: GST Tag
Target: SAE1
Expressed Host: Baculovirus-Insect Cells
Sequence: Amino Acid: Full Length
Tag: GST Tag
Target: SAE1
Expressed Host: Baculovirus-Insect Cells
Sequence: Amino Acid: 1-346
Target: SAE1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 9D8
Application*: E, WB, IF
Target: SAE1
Specificity: Human
Target: SAE1
Specificity: Human
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(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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