SAE1

Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. SAE1 and UBA2 (MIM 613295) form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins (Okuma et al., 1999 [PubMed 9920803]).[supplied by OMIM, Mar 2010]
Full Name
SUMO1 Activating Enzyme Subunit 1
Function
The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2.
Biological Process
Biological Process positive regulation of protein sumoylationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of protein targeting to mitochondrionManual Assertion Based On ExperimentHMP:ParkinsonsUK-UCL
Biological Process protein modification by small protein conjugationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process protein sumoylationManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Nucleus
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Anti-SAE1 antibodies

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Mouse Anti-SAE1 Recombinant Antibody (1G4-1G5) (CBMAB-A7882-LY)

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Target: SAE1
Host: Mouse
Antibody Isotype: IgG1, λ
Specificity: Human
Clone: 1G4-1G5
Application*: WB, E
Datasheet SDS

Mouse Anti-SAE1 Recombinant Antibody (CBXS-3471) (CBMAB-S6202-CQ)

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Target: SAE1
Host: Mouse
Specificity: Human
Clone: CBXS-3471
Application*: DB, WB
Datasheet SDS

Rabbit Anti-SAE1 Recombinant Antibody (CBXS-1402) (CBMAB-S4260-CQ)

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Target: SAE1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Rat, Human
Clone: CBXS-1402
Application*: WB, IP, F, IF
Datasheet SDS

Rabbit Anti-SAE1 Recombinant Antibody (CBXS-1401) (CBMAB-S4259-CQ)

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Target: SAE1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Human
Clone: CBXS-1401
Application*: WB, IF
Datasheet SDS

Mouse Anti-SAE1 Recombinant Antibody (CBXS-1072) (CBMAB-S3962-CQ)

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Target: SAE1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-1072
Application*: E
Datasheet SDS

Mouse Anti-SAE1 Recombinant Antibody (CBXS-4802) (CBMAB-S2028-CQ)

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Target: SAE1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4802
Application*: P, WB
Datasheet SDS

Mouse Anti-SAE1 Recombinant Antibody (CBXS-4793) (CBMAB-S2019-CQ)

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Target: SAE1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-4793
Application*: WB
Datasheet SDS

Mouse Anti-SAE1 Recombinant Antibody (CBXS-4386) (CBMAB-S1629-CQ)

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Target: SAE1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4386
Application*: WB
Datasheet SDS

Mouse Anti-SAE1 Recombinant Antibody (CBXS-4312) (CBMAB-S1557-CQ)

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Target: SAE1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4312
Application*: DB, IC, IF, WB
Datasheet SDS

Mouse Anti-SAE1 Recombinant Antibody (CBXS-4192) (CBMAB-S1445-CQ)

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Target: SAE1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-4192
Application*: IF, P, WB
Datasheet SDS

Mouse Anti-SAE1 Recombinant Antibody (CBXS-4172) (CBMAB-S1425-CQ)

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Target: SAE1
Host: Mouse
Antibody Isotype: IgG1, λ
Specificity: Human
Clone: CBXS-4172
Application*: WB, E, IH, IF
Datasheet SDS

Mouse Anti-SAE1 Recombinant Antibody (CBXS-5806) (CBMAB-S0662-CQ)

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Target: SAE1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-5806
Application*: P, WB
Datasheet SDS

Mouse Anti-SAE1 Recombinant Antibody (CBXS-5796) (CBMAB-S0654-CQ)

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Target: SAE1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-5796
Application*: WB, IH
Datasheet SDS

Rabbit Anti-SAE1 Recombinant Antibody (
9D8) (V2LY-0725-LY1574)

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Target: SAE1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 9D8
Application*: E, WB, IF
Datasheet SDS

SAE1 Matched Antibody Pair (1039) (APMAB-1039LY)

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Target: SAE1
Specificity: Human
Datasheet SDS

SAE1 Matched Antibody Pair (1038) (APMAB-1038LY)

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Target: SAE1
Specificity: Human
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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