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SAE1

Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. SAE1 and UBA2 (MIM 613295) form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins (Okuma et al., 1999 [PubMed 9920803]).[supplied by OMIM, Mar 2010]

Full Name

SUMO1 Activating Enzyme Subunit 1

Function

The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2.

Biological Process

Biological Process positive regulation of protein sumoylationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of protein targeting to mitochondrionManual Assertion Based On ExperimentHMP:ParkinsonsUK-UCL
Biological Process protein modification by small protein conjugationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process protein sumoylationManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Nucleus

Anti-SAE1 antibodies

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

Mouse Anti-SAE1 Recombinant Antibody (1G4-1G5) (CBMAB-A7882-LY)

SDS

Target: SAE1

Host: Mouse

Antibody Isotype: IgG1, λ

Specificity: Human

Clone: 1G4-1G5

Application*: WB, E

Mouse Anti-SAE1 Recombinant Antibody (CBXS-3471) (CBMAB-S6202-CQ)

SDS

Target: SAE1

Host: Mouse

Specificity: Human

Clone: CBXS-3471

Application*: DB, WB

Rabbit Anti-SAE1 Recombinant Antibody (CBXS-1402) (CBMAB-S4260-CQ)

SDS

Target: SAE1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Rat, Human

Clone: CBXS-1402

Application*: WB, IP, F, IF

Rabbit Anti-SAE1 Recombinant Antibody (CBXS-1401) (CBMAB-S4259-CQ)

SDS

Target: SAE1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Mouse, Human

Clone: CBXS-1401

Application*: WB, IF

Mouse Anti-SAE1 Recombinant Antibody (CBXS-1072) (CBMAB-S3962-CQ)

SDS

Target: SAE1

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBXS-1072

Application*: E

Mouse Anti-SAE1 Recombinant Antibody (CBXS-4802) (CBMAB-S2028-CQ)

SDS

Target: SAE1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXS-4802

Application*: P, WB

Mouse Anti-SAE1 Recombinant Antibody (CBXS-4793) (CBMAB-S2019-CQ)

SDS

Target: SAE1

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBXS-4793

Application*: WB

Mouse Anti-SAE1 Recombinant Antibody (CBXS-4386) (CBMAB-S1629-CQ)

SDS

Target: SAE1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXS-4386

Application*: WB

Mouse Anti-SAE1 Recombinant Antibody (CBXS-4312) (CBMAB-S1557-CQ)

SDS

Target: SAE1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXS-4312

Application*: DB, IC, IF, WB

Mouse Anti-SAE1 Recombinant Antibody (CBXS-4192) (CBMAB-S1445-CQ)

SDS

Target: SAE1

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBXS-4192

Application*: IF, P, WB

Mouse Anti-SAE1 Recombinant Antibody (CBXS-4172) (CBMAB-S1425-CQ)

SDS

Target: SAE1

Host: Mouse

Antibody Isotype: IgG1, λ

Specificity: Human

Clone: CBXS-4172

Application*: WB, E, IH, IF

Mouse Anti-SAE1 Recombinant Antibody (CBXS-5806) (CBMAB-S0662-CQ)

SDS

Target: SAE1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXS-5806

Application*: P, WB

Mouse Anti-SAE1 Recombinant Antibody (CBXS-5796) (CBMAB-S0654-CQ)

SDS

Target: SAE1

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBXS-5796

Application*: WB, IH

SAE1 Matched Antibody Pair (1039) (APMAB-1039LY)

SDS

Target: SAE1

Specificity: Human

SAE1 Matched Antibody Pair (1038) (APMAB-1038LY)

SDS

Target: SAE1

Specificity: Human

More Infomation

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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