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Mouse Anti-SAG (C-Term) Recombinant Antibody (CBXS-2483) (CBMAB-S5240-CQ)

This product is a mouse antibody that recognizes SAG. The antibody CBXS-2483 can be used for immunoassay techniques such as: IF, WB.
See all SAG antibodies

Summary

Host Animal
Mouse
Specificity
Cattle, Human, Pig, Rat
Clone
CBXS-2483
Antibody Isotype
IgG1, κ
Application
IF, WB

Basic Information

Immunogen
Raised against recombinant bovine arrestin-1 with the first 20 amino acids of the C-terminus truncated
Specificity
Cattle, Human, Pig, Rat
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
10 mM sodium azide
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
C-Term

Target

Full Name
S-antigen visual arrestin
Introduction
Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. S-arrestin, also known as S-antigen, is a major soluble photoreceptor protein that is involved in desensitization of the photoactivated transduction cascade. It is expressed in the retina and the pineal gland and inhibits coupling of rhodopsin to transducin in vitro. Additionally, S-arrestin is highly antigenic, and is capable of inducing experimental autoimmune uveoretinitis. Mutations in this gene have been associated with Oguchi disease, a rare autosomal recessive form of night blindness.
Entrez Gene ID
Human6295
Pig397151
Rat25539
Cattle280922
UniProt ID
HumanP10523
PigP79260
RatP15887
CattleP08168
Alternative Names
S-Antigen Visual Arrestin; S-Antigen; Retina And Pineal Gland (Arrestin); Rod Photoreceptor Arrestin; 48 KDa Protein; Rod Arrestin; Arrestin 1;
Function
Binds to photoactivated, phosphorylated RHO and terminates RHO signaling via G-proteins by competing with G-proteins for the same binding site on RHO (By similarity).
May play a role in preventing light-dependent degeneration of retinal photoreceptor cells (PubMed:9565049).
Biological Process
Biological Process cell surface receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Biological Process G protein-coupled receptor internalizationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process rhodopsin mediated signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Cell projection, cilium, photoreceptor outer segment
Membrane
Highly expressed in photoreceptor outer segments in light-exposed retina. Evenly distributed throughout rod photoreceptor cells in dark-adapted retina (By similarity).
Predominantly dectected at the proximal region of photoreceptor outer segments, near disk membranes (PubMed:3720866).
Involvement in disease
Night blindness, congenital stationary, Oguchi type 1 (CSNBO1):
A non-progressive retinal disorder characterized by impaired night vision, often associated with nystagmus and myopia. Congenital stationary night blindness Oguchi type is an autosomal recessive form associated with fundus discoloration and abnormally slow dark adaptation.
Retinitis pigmentosa 47 (RP47):
A retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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