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Mouse Anti-SALL4 Recombinant Antibody (6E3) (CBMAB-S2883-CQ)

This product is a mouse antibody that recognizes SALL4. The antibody 6E3 can be used for immunoassay techniques such as: ELISA, WB.
See all SALL4 antibodies
Published Data

Summary

Host Animal
Mouse
Specificity
Human
Clone
6E3
Antibody Isotype
IgG1, κ
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Spalt Like Transcription Factor 4
Introduction
This gene encodes a zinc finger transcription factor thought to play a role in the development of abducens motor neurons. Defects in this gene are a cause of Duane-radial ray syndrome (DRRS). Alternative splicing results in multiple transcript variants encoding different isoforms.
Entrez Gene ID
UniProt ID
Alternative Names
Spalt Like Transcription Factor 4; Zinc Finger Protein SALL4; Zinc Finger Protein 797; ZNF797; Sal (Drosophila)-Like 4; Sal-Like 4 (Drosophila); Sal-Like Protein 4; HSAL4; DRRS;
Function
Transcription factor with a key role in the maintenance and self-renewal of embryonic and hematopoietic stem cells.
Biological Process
Biological Process embryonic limb morphogenesisIEA:Ensembl
Biological Process inner cell mass cell proliferationIEA:Ensembl
Biological Process negative regulation of transcription by RNA polymerase IIIEA:Ensembl
Biological Process neural tube closureIEA:Ensembl
Biological Process positive regulation of transcription by RNA polymerase IIIEA:Ensembl
Biological Process regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Biological Process somatic stem cell population maintenanceIEA:Ensembl
Biological Process ventricular septum developmentIEA:Ensembl
Cellular Location
Cytoplasm
Nucleus
Involvement in disease
Duane-radial ray syndrome (DRRS):
Disorder characterized by the association of forearm malformations with Duane retraction syndrome.
IVIC syndrome (IVIC):
An autosomal dominant condition characterized by upper limbs anomalies (radial ray defects, carpal bones fusion), extraocular motor disturbances, congenital bilateral non-progressive mixed hearing loss. Other less consistent malformations include heart involvement, mild thrombocytopenia and leukocytosis (before age 50), shoulder girdle hypoplasia, imperforate anus, kidney malrotation or rectovaginal fistula. The IVIC syndrome is an allelic disorder of Duane-radial ray syndrome with a similar phenotype.
PTM
Isoform SALL4B exists primarily as a ubiquitinated form.
Sumoylation with both SUMO1 and SUMO2 regulates the stability, subcellular localization, transcriptional activity, and may reduce interaction with POU5F1/OCT4.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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