SALL4

This gene encodes a zinc finger transcription factor thought to play a role in the development of abducens motor neurons. Defects in this gene are a cause of Duane-radial ray syndrome (DRRS). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]
Full Name
Spalt Like Transcription Factor 4
Function
Transcription factor with a key role in the maintenance and self-renewal of embryonic and hematopoietic stem cells.
Biological Process
Biological Process embryonic limb morphogenesisIEA:Ensembl
Biological Process inner cell mass cell proliferationIEA:Ensembl
Biological Process negative regulation of transcription by RNA polymerase IIIEA:Ensembl
Biological Process neural tube closureIEA:Ensembl
Biological Process positive regulation of transcription by RNA polymerase IIIEA:Ensembl
Biological Process regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Biological Process somatic stem cell population maintenanceIEA:Ensembl
Biological Process ventricular septum developmentIEA:Ensembl
Cellular Location
Cytoplasm
Nucleus
Involvement in disease
Duane-radial ray syndrome (DRRS):
Disorder characterized by the association of forearm malformations with Duane retraction syndrome.
IVIC syndrome (IVIC):
An autosomal dominant condition characterized by upper limbs anomalies (radial ray defects, carpal bones fusion), extraocular motor disturbances, congenital bilateral non-progressive mixed hearing loss. Other less consistent malformations include heart involvement, mild thrombocytopenia and leukocytosis (before age 50), shoulder girdle hypoplasia, imperforate anus, kidney malrotation or rectovaginal fistula. The IVIC syndrome is an allelic disorder of Duane-radial ray syndrome with a similar phenotype.
PTM
Isoform SALL4B exists primarily as a ubiquitinated form.
Sumoylation with both SUMO1 and SUMO2 regulates the stability, subcellular localization, transcriptional activity, and may reduce interaction with POU5F1/OCT4.
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Anti-SALL4 antibodies

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Mouse Anti-SALL4 Recombinant Antibody (CF382) (CBMAB-FT129LY)

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Target: SALL4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CF382
Application*: ELISA, WB
Datasheet SDS

Mouse Anti-SALL4 Recombinant Antibody (6E3) (CBMAB-S2883-CQ)

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Target: SALL4
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 6E3
Application*: E, WB
Datasheet SDS

Mouse Anti-SALL4 Recombinant Antibody (CBT2213) (V2LY-0625-LY347)

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Target: SALL4
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBT2213
Application*: F
Datasheet SDS

Mouse Anti-SALL4 Recombinant Antibody (CBT4329) (V2LY-0625-LY1627)

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Target: SALL4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT4329
Application*: F
Datasheet SDS

Mouse Anti-SALL4 Recombinant Antibody (CBT3700) (V2LY-0625-LY1626)

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Target: SALL4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3700
Application*: IC, F
Datasheet SDS

Mouse Anti-SALL4 Recombinant Antibody (CBT3055) (V2LY-0625-LY1500)

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Target: SALL4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3055
Application*: F
Datasheet SDS

Mouse Anti-SALL4 Recombinant Antibody (CBT2983) (V2LY-0625-LY1484)

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Target: SALL4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT2983
Application*: WB, F
Datasheet SDS

Mouse Anti-SALL4 Recombinant Antibody (CBT2307) (V2LY-0625-LY1483)

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Target: SALL4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT2307
Application*: WB, F
Datasheet SDS

Mouse Anti-SALL4 Recombinant Antibody (CBT2657) (V2LY-0625-LY1482)

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Target: SALL4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT2657
Application*: WB, F
Datasheet SDS

Mouse Anti-SALL4 Recombinant Antibody (IHC659) (CBMAB-MA216-YC)

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Target: SALL4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: IHC659
Application*: P, E, IH
Datasheet SDS

Rabbit Anti-SALL4 Recombinant Antibody (D16H12) (CBMAB-CP2344-LY)

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Target: SALL4
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: D16H12
Application*: WB, IF (IC)
Datasheet SDS

Mouse Anti-SALL4 Recombinant Antibody (CBXS-2399) (CBMAB-S5156-CQ)

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Target: SALL4
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-2399
Application*: IH, WB
Datasheet SDS

Mouse Anti-SALL4 Recombinant Antibody (CBXS-2243) (CBMAB-S5005-CQ)

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Target: SALL4
Host: Mouse
Specificity: Mouse, Rat, Human
Clone: CBXS-2243
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-SALL4 Recombinant Antibody (CBXS-2212) (CBMAB-S4974-CQ)

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Target: SALL4
Host: Mouse
Specificity: Mouse
Clone: CBXS-2212
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-SALL4 Recombinant Antibody (CBXS-1873) (CBMAB-S4669-CQ)

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Target: SALL4
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse
Clone: CBXS-1873
Application*: WB, IH
Datasheet SDS

Rabbit Anti-SALL4 Recombinant Antibody (CBXS-1255) (CBMAB-S4114-CQ)

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Target: SALL4
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXS-1255
Application*: P
Datasheet SDS

Mouse Anti-SALL4 Recombinant Antibody (CBXS-0117) (CBMAB-S3112-CQ)

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Target: SALL4
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXS-0117
Application*: SE, P, E, WB
Datasheet SDS

Mouse Anti-SALL4 (AA 96-359) Recombinant Antibody (CBXS-0116) (CBMAB-S3111-CQ)

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Target: SALL4
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-0116
Application*: IH, WB
Datasheet SDS

Rabbit Anti-SALL4 Recombinant Antibody (CBXS-5339) (CBMAB-S2552-CQ)

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Target: SALL4
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXS-5339
Application*: WB, IF
Datasheet SDS

Mouse Anti-SALL4 Recombinant Antibody (CBXS-4704) (CBMAB-S1935-CQ)

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Target: SALL4
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-4704
Application*: IH, WB
Datasheet SDS

Mouse Anti-SALL4 Recombinant Antibody (CBXS-4401) (CBMAB-S1643-CQ)

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Target: SALL4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4401
Application*: E, WB
Datasheet SDS

Mouse Anti-SALL4 Recombinant Antibody (CBXS-4040) (CBMAB-S1301-CQ)

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Target: SALL4
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXS-4040
Application*: E, WB, F
Datasheet SDS

Rabbit Anti-SALL4 Recombinant Antibody (CBXS-3747) (CBMAB-S1020-CQ)

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Target: SALL4
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXS-3747
Application*: CI, F, IC, IF
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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