Rabbit Anti-SAR1B Recombinant Antibody (CBXS-1244) (CBMAB-S4103-CQ)

Name: Rabbit Anti-SAR1B Recombinant Antibody (CBXS-1244)
SKU: CBMAB-S4103-CQ
Rating: 5 (1 reviews)

See all SAR1B antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

CBXS-1244

Application

WB, IP, IHC-P, ICC, FC

Specificity

Mouse, Rat, Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Secretion Associated Ras Related GTPase 1B

Introduction

The protein encoded by this gene is a small GTPase that acts as a homodimer. The encoded protein is activated by the guanine nucleotide exchange factor PREB and is involved in protein transport from the endoplasmic reticulum to the Golgi. This protein is part of the COPII coat complex. Defects in this gene are a cause of chylomicron retention disease (CMRD), also known as Anderson disease (ANDD). Two transcript variants encoding the same protein have been found for this gene.

Entrez Gene ID

Human	51128
Mouse	66397
Rat	287276

UniProt ID

Human	Q9Y6B6
Mouse	Q9CQC9
Rat	Q5HZY2

Alternative Names

Secretion Associated Ras Related GTPase 1B; GTP-Binding Protein B; SARA2; GTBPB; Secretion Associated, Ras Related GTPase 1B; SAR1a Gene Homolog (S. Cerevisiae) 2; SAR1a Gene Homolog 2 (S. Cerevisiae); SAR1 Homolog B (S. Cerevisiae); GTP-Binding Protein SAR1b;

Function

GTP-binding protein involved in transport from the endoplasmic reticulum to the Golgi apparatus (By similarity).
Activated by the guanine nucleotide exchange factor PREB (By similarity).
Involved in the selection of the protein cargo and the assembly of the COPII coat complex (By similarity).
Synergizes with the cargo receptor SURF4 to mediate the export of lipoproteins from the endoplasmic reticulum, thereby regulating lipoprotein delivery and the maintenance of lipid homeostasis (PubMed:33186557).

Biological Process

Biological Process antigen processing and presentation of peptide antigen via MHC class ITAS:Reactome
Biological Process endoplasmic reticulum to Golgi vesicle-mediated transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process intracellular protein transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process lipid homeostasisManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process lipoprotein transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process membrane organizationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of protein exit from endoplasmic reticulumManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of COPII vesicle coatingManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of lipid transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process vesicle organizationManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Endoplasmic reticulum membrane
Golgi apparatus, Golgi stack membrane
Associated with the endoplasmic reticulum and Golgi stacks, in particular in the juxta-nuclear Golgi region.

Involvement in disease

Chylomicron retention disease (CMRD):
An autosomal recessive disorder of severe fat malabsorption associated with failure to thrive in infancy. The condition is characterized by deficiency of fat-soluble vitamins, low blood cholesterol levels, and a selective absence of chylomicrons from blood. Affected individuals accumulate chylomicron-like particles in membrane-bound compartments of enterocytes, which contain large cytosolic lipid droplets.

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Rabbit Anti-SAR1B Recombinant Antibody (CBXS-1244)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

Mouse Anti-SAR1B Recombinant Antibody (CBXS-3938) (CAT#: CBMAB-S0226-CQ)

Mouse Anti-SAR1B Recombinant Antibody (CBXS-2604) (CAT#: CBMAB-S5359-CQ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry