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Mouse Anti-SAR1B Recombinant Antibody (CBXS-2604) (CBMAB-S5359-CQ)

This product is a mouse antibody that recognizes SAR1B. The antibody CBXS-2604 can be used for immunoassay techniques such as: ELISA, WB.
See all SAR1B antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-2604
Application
ELISA, WB

Basic Information

Immunogen
Recombinant protein corresponding to aa1-198 from human SAR1B
Specificity
Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4, 10% glycerol
Preservative
0.02% sodium azide
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Secretion Associated Ras Related GTPase 1B
Introduction
The protein encoded by this gene is a small GTPase that acts as a homodimer. The encoded protein is activated by the guanine nucleotide exchange factor PREB and is involved in protein transport from the endoplasmic reticulum to the Golgi. This protein is part of the COPII coat complex. Defects in this gene are a cause of chylomicron retention disease (CMRD), also known as Anderson disease (ANDD). Two transcript variants encoding the same protein have been found for this gene.
Entrez Gene ID
51128
UniProt ID
Q9Y6B6
Alternative Names
Secretion Associated Ras Related GTPase 1B; GTP-Binding Protein B; SARA2; GTBPB; Secretion Associated, Ras Related GTPase 1B; SAR1a Gene Homolog (S. Cerevisiae) 2; SAR1a Gene Homolog 2 (S. Cerevisiae); SAR1 Homolog B (S. Cerevisiae); GTP-Binding Protein SAR1b;
Function
GTP-binding protein involved in transport from the endoplasmic reticulum to the Golgi apparatus (By similarity).
Activated by the guanine nucleotide exchange factor PREB (By similarity).
Involved in the selection of the protein cargo and the assembly of the COPII coat complex (By similarity).
Synergizes with the cargo receptor SURF4 to mediate the export of lipoproteins from the endoplasmic reticulum, thereby regulating lipoprotein delivery and the maintenance of lipid homeostasis (PubMed:33186557).
Biological Process
Biological Process antigen processing and presentation of peptide antigen via MHC class ITAS:Reactome
Biological Process endoplasmic reticulum to Golgi vesicle-mediated transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process intracellular protein transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process lipid homeostasisManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process lipoprotein transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process membrane organizationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of protein exit from endoplasmic reticulumManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of COPII vesicle coatingManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of lipid transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process vesicle organizationManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Endoplasmic reticulum membrane
Golgi apparatus, Golgi stack membrane
Associated with the endoplasmic reticulum and Golgi stacks, in particular in the juxta-nuclear Golgi region.
Involvement in disease
Chylomicron retention disease (CMRD):
An autosomal recessive disorder of severe fat malabsorption associated with failure to thrive in infancy. The condition is characterized by deficiency of fat-soluble vitamins, low blood cholesterol levels, and a selective absence of chylomicrons from blood. Affected individuals accumulate chylomicron-like particles in membrane-bound compartments of enterocytes, which contain large cytosolic lipid droplets.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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