Rabbit Anti-SARM1 Recombinant Antibody (CBXS-5370) (CBMAB-S2583-CQ)

Name: Rabbit Anti-SARM1 Recombinant Antibody (CBXS-5370)
SKU: CBMAB-S2583-CQ
Rating: 5 (1 reviews)

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Datasheet

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Basic Information

Host Animal

Rabbit

Clone

CBXS-5370

Application

WB, IP, IF

Specificity

Human

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Sterile Alpha And TIR Motif Containing 1

Introduction

SARM1 (Sterile Alpha And TIR Motif Containing 1) is a Protein Coding gene. Diseases associated with SARM1 include Wallerian Degeneration. Among its related pathways are Innate Immune System and Activated TLR4 signalling. Gene Ontology (GO) annotations related to this gene include binding.

Entrez Gene ID

23098

UniProt ID

Q6SZW1

Alternative Names

Sterile Alpha And TIR Motif Containing 1; Sterile Alpha Motif Domain-Containing Protein 2; Sterile Alpha And Armadillo Repeat Protein; SAM Domain-Containing Protein 2; Tir-1 Homolog; MyD88-5;

Function

NAD+ hydrolase, which plays a key role in axonal degeneration following injury by regulating NAD+ metabolism (PubMed:25908823, PubMed:27671644, PubMed:28334607).
Acts as a negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway by promoting Wallerian degeneration, an injury-induced form of programmed subcellular death which involves degeneration of an axon distal to the injury site (PubMed:15123841, PubMed:16964262, PubMed:20306472, PubMed:25908823).
Wallerian degeneration is triggered by NAD+ depletion: in response to injury, SARM1 is activated and catalyzes cleavage of NAD+ into ADP-D-ribose (ADPR), cyclic ADPR (cADPR) and nicotinamide; NAD+ cleavage promoting cytoskeletal degradation and axon destruction (PubMed:25908823, PubMed:28334607, PubMed:30333228, PubMed:31128467, PubMed:31439793, PubMed:32049506, PubMed:32828421, PubMed:31439792, PubMed:33053563).
Also able to hydrolyze NADP+, but not other NAD+-related molecules (PubMed:29395922).
Can activate neuronal cell death in response to stress (PubMed:20306472).
Regulates dendritic arborization through the MAPK4-JNK pathway (By similarity).
Involved in innate immune response: inhibits both TICAM1/TRIF- and MYD88-dependent activation of JUN/AP-1, TRIF-dependent activation of NF-kappa-B and IRF3, and the phosphorylation of MAPK14/p38 (PubMed:16964262).

Biological Process

Biological Process cell differentiationIEA:UniProtKB-KW
Biological Process innate immune responseIEA:UniProtKB-KW
Biological Process NAD catabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of MyD88-independent toll-like receptor signaling pathwayIEA:InterPro
Biological Process nervous system developmentIEA:UniProtKB-KW
Biological Process positive regulation of neuron deathManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of dendrite morphogenesisISS:UniProtKB
Biological Process regulation of neuron apoptotic processIEA:Ensembl
Biological Process regulation of neuron deathISS:UniProtKB
Biological Process response to axon injuryManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process response to glucoseIEA:Ensembl
Biological Process signal transductionIEA:InterPro

Cellular Location

Cytoplasm
Cell projection, axon
Cell projection, dendrite
Synapse
Mitochondrion
Associated with microtubules.

PTM

Phosphorylation at Ser-548 by JNK kinases (MAPK8, MAPK9 and /or MAPK10) enhance the NAD+ hydrolase (NADase) activity (PubMed:30333228).
Phosphorylation at Ser-548 and subsequent activation takes place in response to oxidative stress conditions and inhibits mitochondrial respiration (PubMed:30333228).

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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