Rabbit Anti-SART1 Recombinant Antibody (CBXS-1385) (CBMAB-S4243-CQ)

Name: Rabbit Anti-SART1 Recombinant Antibody (CBXS-1385)
SKU: CBMAB-S4243-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Rabbit

Clone

CBXS-1385

Application

WB, FC, IF

Specificity

Mouse, Rat, Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration

0.761 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

SART1, U4/U6.U5 Tri-SnRNP-Associated Protein 1

Introduction

This gene encodes two proteins, the SART1(800) protein expressed in the nucleus of the majority of proliferating cells, and the SART1(259) protein expressed in the cytosol of epithelial cancers. The SART1(259) protein is translated by the mechanism of -1 frameshifting during posttranscriptional regulation; its full-length sequence is not published yet. The two encoded proteins are thought to be involved in the regulation of proliferation. Both proteins have tumor-rejection antigens. The SART1(259) protein possesses tumor epitopes capable of inducing HLA-A2402-restricted cytotoxic T lymphocytes in cancer patients. This SART1(259) antigen may be useful in specific immunotherapy for cancer patients and may serve as a paradigmatic tool for the diagnosis and treatment of patients with atopy. The SART1(259) protein is found to be essential for the recruitment of the tri-snRNP to the pre-spliceosome in the spliceosome assembly pathway.

Entrez Gene ID

Human	9092
Mouse	20227
Rat	29678

UniProt ID

Human	O43290
Mouse	Q9Z315
Rat	Q5XIW8

Alternative Names

SART1, U4/U6.U5 Tri-SnRNP-Associated Protein 1; Squamous Cell Carcinoma Antigen Recognized By T-Cells 1; Squamous Cell Carcinoma Antigen Recognised By T Cells; Small Nuclear Ribonucleoprotein 110kDa (U4/U6.U5); U4/U6.U5 Tri-SnRNP-Associated 110 KDa Protein; Hypoxia Associated Factor; SNU66 Homolog; HSART-1; SART-1; HSnu66; Squamous Cell Carcinoma Antigen Recognized By T Cells 1; U4/U6.U5 Tri-SnRNP-Associated Protein 1;

Function

Plays a role in mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the spliceosome. May also bind to DNA.

Biological Process

Biological Process maturation of 5S rRNAManual Assertion Based On ExperimentIBA:GO_Central
Biological Process mRNA cis splicing, via spliceosomeManual Assertion Based On ExperimentIBA:GO_Central
Biological Process mRNA splicing, via spliceosomeManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of cytotoxic T cell differentiationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process spliceosomal snRNP assemblyManual Assertion Based On ExperimentTAS:BHF-UCL

Cellular Location

Nucleus
Found in the nucleus of mitogen-activated peripheral blood mononuclear cells (PBMCs), tumor cells, or normal cell lines, but not in normal tissues except testis and fetal liver or in unstimulated PBMCs, suggesting preferential expression in proliferating cells.

PTM

Sumoylated with SUMO2.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Mouse Anti-SART1 Recombinant Antibody (2A9) (CAT#: CBMAB-0799CQ)

Mouse Anti-SART1 Recombinant Antibody (CBXS-1958) (CAT#: CBMAB-S4734-CQ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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