SART1

This gene encodes two proteins, the SART1(800) protein expressed in the nucleus of the majority of proliferating cells, and the SART1(259) protein expressed in the cytosol of epithelial cancers. The SART1(259) protein is translated by the mechanism of -1 frameshifting during posttranscriptional regulation; its full-length sequence is not published yet. The two encoded proteins are thought to be involved in the regulation of proliferation. Both proteins have tumor-rejection antigens. The SART1(259) protein possesses tumor epitopes capable of inducing HLA-A2402-restricted cytotoxic T lymphocytes in cancer patients. This SART1(259) antigen may be useful in specific immunotherapy for cancer patients and may serve as a paradigmatic tool for the diagnosis and treatment of patients with atopy. The SART1(259) protein is found to be essential for the recruitment of the tri-snRNP to the pre-spliceosome in the spliceosome assembly pathway.

Full Name

SART1, U4/U6.U5 Tri-SnRNP-Associated Protein 1

Function

Plays a role in mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the spliceosome. May also bind to DNA.

Biological Process

Biological Process maturation of 5S rRNAManual Assertion Based On ExperimentIBA:GO_Central
Biological Process mRNA cis splicing, via spliceosomeManual Assertion Based On ExperimentIBA:GO_Central
Biological Process mRNA splicing, via spliceosomeManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of cytotoxic T cell differentiationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process spliceosomal snRNP assemblyManual Assertion Based On ExperimentTAS:BHF-UCL

Cellular Location

Nucleus
Found in the nucleus of mitogen-activated peripheral blood mononuclear cells (PBMCs), tumor cells, or normal cell lines, but not in normal tissues except testis and fetal liver or in unstimulated PBMCs, suggesting preferential expression in proliferating cells.

PTM

Sumoylated with SUMO2.