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Mouse Anti-SAV1 Recombinant Antibody (3A10) (CBMAB-A7897-LY)

The product is antibody recognizes SAV1. The antibody 3A10 immunoassay techniques such as: WB, ELISA.
See all SAV1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
3A10
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
SAV1 (NP_068590, 300 a.a. ~ 383 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Salvador Family WW Domain Containing Protein 1
Introduction
WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 2 WW domains and a coiled-coil region. It is ubiquitously expressed in adult tissues. The encoded protein is 94% identical to the mouse protein at the amino acid level. [provided by RefSeq]
Entrez Gene ID
60485
UniProt ID
Q9H4B6
Alternative Names
SAV; WW45; WWP4
Function
Regulator of STK3/MST2 and STK4/MST1 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. SAV1 is required for STK3/MST2 and STK4/MST1 activation and promotes cell-cycle exit and terminal differentiation in developing epithelial tissues. Plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosomes, and its ability to phosphorylate CROCC and CEP250. In conjunction with STK3/MST2, activates the transcriptional activity of ESR1 through the modulation of its phosphorylation.
Biological Process
Biological Process cardiac muscle cell proliferationIEA:Ensembl
Biological Process epithelial cell proliferationIEA:Ensembl
Biological Process hair follicle developmentIEA:Ensembl
Biological Process hippo signalingISS:UniProtKB
Biological Process intestinal epithelial cell differentiationIEA:Ensembl
Biological Process keratinocyte apoptotic processIEA:Ensembl
Biological Process keratinocyte differentiationIEA:Ensembl
Biological Process lung epithelial cell differentiationIEA:Ensembl
Biological Process negative regulation of cardiac muscle cell proliferationIEA:Ensembl
Biological Process negative regulation of epithelial cell proliferationIEA:Ensembl
Biological Process positive regulation of DNA-binding transcription factor activityIEA:Ensembl
Biological Process positive regulation of fat cell differentiationIEA:Ensembl
Biological Process positive regulation of keratinocyte apoptotic processIEA:Ensembl
Biological Process protein stabilizationIEA:Ensembl
Biological Process receptor clusteringManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of stem cell population maintenanceIEA:Ensembl
Biological Process signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process ventricular septum morphogenesisIEA:Ensembl
Cellular Location
Nucleus
Cytoplasm
PTM
Phosphorylated by STK3/MST2 and STK4/MST1. Phosphorylation is not required for SAV1 stability and may increase the number of protein binding sites on the scaffold molecule.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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