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Rabbit Anti-SAV1 Recombinant Antibody (CBXS-5424) (CBMAB-S2635-CQ)

This product is a rabbit antibody that recognizes SAV1. The antibody CBXS-5424 can be used for immunoassay techniques such as: WB, IP, IF.
See all SAV1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse
Clone
CBXS-5424
Application
WB, IP, IF

Basic Information

Specificity
Human, Mouse
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Salvador Family WW Domain Containing Protein 1
Introduction
WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein with two WW domains, a SARAH domain, and a coiled-coil region and is ubiquitously expressed in adult tissues. This protein binds to MST1 (mammalian sterile 20-like kinase 1) and promotes MST1-induced apoptosis. It has also been shown to bind to HAX1 (hematopoietic cell-specific protein 1 (HS1)-associated protein X-1) and to attenuate the anti-apoptotic effects of HAX1. Studies in human and mouse suggest this gene acts as a tumor suppressor.
Entrez Gene ID
Human60485
Mouse64010
UniProt ID
HumanQ9H4B6
MouseQ8VEB2
Alternative Names
Salvador Family WW Domain Containing Protein 1; WW Domain-Containing Adaptor 45; 45 KDa WW Domain Protein; HWW45; WW45; Salvador Homolog 1 (Drosophila);
Function
Regulator of STK3/MST2 and STK4/MST1 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. SAV1 is required for STK3/MST2 and STK4/MST1 activation and promotes cell-cycle exit and terminal differentiation in developing epithelial tissues. Plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosomes, and its ability to phosphorylate CROCC and CEP250. In conjunction with STK3/MST2, activates the transcriptional activity of ESR1 through the modulation of its phosphorylation.
Biological Process
Biological Process cardiac muscle cell proliferationIEA:Ensembl
Biological Process epithelial cell proliferationIEA:Ensembl
Biological Process hair follicle developmentIEA:Ensembl
Biological Process hippo signalingISS:UniProtKB
Biological Process intestinal epithelial cell differentiationIEA:Ensembl
Biological Process keratinocyte apoptotic processIEA:Ensembl
Biological Process keratinocyte differentiationIEA:Ensembl
Biological Process lung epithelial cell differentiationIEA:Ensembl
Biological Process negative regulation of cardiac muscle cell proliferationIEA:Ensembl
Biological Process negative regulation of epithelial cell proliferationIEA:Ensembl
Biological Process positive regulation of DNA-binding transcription factor activityIEA:Ensembl
Biological Process positive regulation of fat cell differentiationIEA:Ensembl
Biological Process positive regulation of keratinocyte apoptotic processIEA:Ensembl
Biological Process protein stabilizationIEA:Ensembl
Biological Process receptor clusteringManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of stem cell population maintenanceIEA:Ensembl
Biological Process signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process ventricular septum morphogenesisIEA:Ensembl
Cellular Location
Nucleus
Cytoplasm
PTM
Phosphorylated by STK3/MST2 and STK4/MST1. Phosphorylation is not required for SAV1 stability and may increase the number of protein binding sites on the scaffold molecule.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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