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Rabbit Anti-SCAI Recombinant Antibody (CBXS-1506) (CBMAB-S4359-CQ)

This product is a rabbit antibody that recognizes SCAI. The antibody CBXS-1506 can be used for immunoassay techniques such as: WB, IHC-P, FC, IF.
See all SCAI antibodies

Summary

Host Animal
Rabbit
Specificity
Mouse, Rat, Human
Clone
CBXS-1506
Antibody Isotype
IgG
Application
WB, IHC-P, FC, IF

Basic Information

Specificity
Mouse, Rat, Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Suppressor Of Cancer Cell Invasion
Introduction
This gene encodes a regulator of cell migration. The encoded protein appears to function in the RhoA (ras homolog gene family, member A)-Dia1 (diaphanous homolog 1) signal transduction pathway. Alternatively spliced transcript variants have been described.
Entrez Gene ID
Human286205
Mouse320271
Rat690538
UniProt ID
HumanQ8N9R8
MouseQ8C8N2
Alternative Names
Suppressor Of Cancer Cell Invasion; Suppressor Of Cancer Cell Invasion Protein; C9orf126; Chromosome 9 Open Reading Frame 126; Protein SCAI; NET40;
Function
Tumor suppressor which functions to suppress MRTFA-induced SRF transcriptional activity. May function in the RHOA-DIAPH1 signal transduction pathway and regulate cell migration through transcriptional regulation of ITGB1.
Biological Process
Biological Process negative regulation of cell migrationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of Rho protein signal transductionISS:UniProtKB
Cellular Location
Membrane
Nucleus
Cytoplasm
Nuclear localization is required for inhibition of MRTFA.
Topology
Helical: 472-492
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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