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Rabbit Anti-SCIN Recombinant Antibody (CBXS-1419) (CBMAB-S4277-CQ)

This product is a rabbit antibody that recognizes SCIN. The antibody CBXS-1419 can be used for immunoassay techniques such as: WB.
See all SCIN antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
CBXS-1419
Antibody Isotype
IgG
Application
WB

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Scinderin
Introduction
SCIN is a Ca(2+)-dependent actin-severing and -capping protein (Zunino et al., 2001 [PubMed 11568009]).
Entrez Gene ID
85477
UniProt ID
Q9Y6U3
Alternative Names
Scinderin; Adseverin; KIAA1905;
Function
Ca2+-dependent actin filament-severing protein that has a regulatory function in exocytosis by affecting the organization of the microfilament network underneath the plasma membrane (PubMed:8547642, PubMed:26365202).
Severing activity is inhibited by phosphatidylinositol 4,5-bis-phosphate (PIP2) (By similarity).
In vitro, also has barbed end capping and nucleating activities in the presence of Ca2+. Required for megakaryocyte differentiation, maturation, polyploidization and apoptosis with the release of platelet-like particles (PubMed:11568009).
Plays a role in osteoclastogenesis (OCG) and actin cytoskeletal organization in osteoclasts (By similarity).
Regulates chondrocyte proliferation and differentiation (By similarity).
Inhibits cell proliferation and tumorigenesis. Signaling is mediated by MAPK, p38 and JNK pathways (PubMed:11568009).
Biological Process
Biological Process actin filament cappingManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process actin filament severingManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process actin nucleationISS:UniProtKB
Biological Process actin polymerization or depolymerizationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process barbed-end actin filament cappingManual Assertion Based On ExperimentIBA:GO_Central
Biological Process calcium-ion regulated exocytosisISS:UniProtKB
Biological Process cell projection assemblyManual Assertion Based On ExperimentIBA:GO_Central
Biological Process central nervous system developmentManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of cell population proliferationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of actin nucleationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of apoptotic processManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of megakaryocyte differentiationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of secretionISS:UniProtKB
Biological Process regulation of chondrocyte differentiationISS:UniProtKB
Biological Process sequestering of actin monomersManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Cytoplasm, cytoskeleton
Cell projection, podosome
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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