SCIN

SCIN is a Ca(2+)-dependent actin-severing and -capping protein (Zunino et al., 2001 [PubMed 11568009]).

Full Name

Scinderin

Function

Ca2+-dependent actin filament-severing protein that has a regulatory function in exocytosis by affecting the organization of the microfilament network underneath the plasma membrane (PubMed:8547642, PubMed:26365202).
Severing activity is inhibited by phosphatidylinositol 4,5-bis-phosphate (PIP2) (By similarity).
In vitro, also has barbed end capping and nucleating activities in the presence of Ca2+. Required for megakaryocyte differentiation, maturation, polyploidization and apoptosis with the release of platelet-like particles (PubMed:11568009).
Plays a role in osteoclastogenesis (OCG) and actin cytoskeletal organization in osteoclasts (By similarity).
Regulates chondrocyte proliferation and differentiation (By similarity).
Inhibits cell proliferation and tumorigenesis. Signaling is mediated by MAPK, p38 and JNK pathways (PubMed:11568009).

Biological Process

Biological Process actin filament cappingManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process actin filament severingManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process actin nucleationISS:UniProtKB
Biological Process actin polymerization or depolymerizationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process barbed-end actin filament cappingManual Assertion Based On ExperimentIBA:GO_Central
Biological Process calcium-ion regulated exocytosisISS:UniProtKB
Biological Process cell projection assemblyManual Assertion Based On ExperimentIBA:GO_Central
Biological Process central nervous system developmentManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of cell population proliferationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of actin nucleationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of apoptotic processManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of megakaryocyte differentiationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of secretionISS:UniProtKB
Biological Process regulation of chondrocyte differentiationISS:UniProtKB
Biological Process sequestering of actin monomersManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Cytoplasm, cytoskeleton
Cell projection, podosome