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Mouse Anti-SCNN1D Recombinant Antibody (CBXS-4582) (CBMAB-S1822-CQ)

This product is a mouse antibody that recognizes SCNN1D. The antibody CBXS-4582 can be used for immunoassay techniques such as: ELISA.
See all SCNN1D antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-4582
Antibody Isotype
IgG2a, κ
Application
ELISA

Basic Information

Immunogen
Partial recombinant corresponding to aa432-531 from human SCNN1D (NP_002969) with GST tag
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
sodium channel, nonvoltage-gated 1, delta
Introduction
SCNN1D (Sodium Channel Epithelial 1 Delta Subunit) is a Protein Coding gene. Diseases associated with SCNN1D include Pseudohypoaldosteronism, Type I, Autosomal Recessive. Among its related pathways are Neuropathic Pain-Signaling in Dorsal Horn Neurons and Activation of cAMP-Dependent PKA. Gene Ontology (GO) annotations related to this gene include sodium channel activity and ligand-gated sodium channel activity. An important paralog of this gene is SCNN1A.
Entrez Gene ID
6339
UniProt ID
P51172
Alternative Names
Sodium Channel Epithelial 1 Delta Subunit; Sodium Channel, Non-Voltage-Gated 1, Delta Subunit; Nonvoltage-Gated Sodium Channel 1 Subunit Delta; Sodium Channel, Nonvoltage-Gated 1, Delta; Epithelial Na(+) Channel Subunit Delta; Delta-ENaC; Delta-NaCH; ENaCd;
Function
Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception.
Biological Process
Biological Process cellular response to acidic pHManual Assertion Based On ExperimentIDA:ComplexPortal
Biological Process cellular response to aldosterone1 PublicationIC:ComplexPortal
Biological Process cellular response to amilorideManual Assertion Based On ExperimentIDA:ComplexPortal
Biological Process cellular response to vasopressin1 PublicationIC:ComplexPortal
Biological Process cellular sodium ion homeostasisManual Assertion Based On ExperimentIDA:ComplexPortal
Biological Process regulation of blood pressure1 PublicationIC:ComplexPortal
Biological Process sensory perception of salty taste1 PublicationIC:ComplexPortal
Biological Process sensory perception of sour taste1 PublicationIC:ComplexPortal
Biological Process sodium ion import across plasma membraneManual Assertion Based On ExperimentIDA:ComplexPortal
Biological Process sodium ion transmembrane transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process sodium ion transportManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Cell membrane
Topology
Cytoplasmic: 1-250
Helical: 251-271
Extracellular: 272-694
Helical: 695-715
Cytoplasmic: 716-802
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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