SCNN1D

SCNN1D (Sodium Channel Epithelial 1 Delta Subunit) is a Protein Coding gene. Diseases associated with SCNN1D include Pseudohypoaldosteronism, Type I, Autosomal Recessive. Among its related pathways are Neuropathic Pain-Signaling in Dorsal Horn Neurons and Activation of cAMP-Dependent PKA. Gene Ontology (GO) annotations related to this gene include sodium channel activity and ligand-gated sodium channel activity. An important paralog of this gene is SCNN1A.

Full Name

sodium channel, nonvoltage-gated 1, delta

Function

Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception.

Biological Process

Biological Process cellular response to acidic pHManual Assertion Based On ExperimentIDA:ComplexPortal
Biological Process cellular response to aldosterone1 PublicationIC:ComplexPortal
Biological Process cellular response to amilorideManual Assertion Based On ExperimentIDA:ComplexPortal
Biological Process cellular response to vasopressin1 PublicationIC:ComplexPortal
Biological Process cellular sodium ion homeostasisManual Assertion Based On ExperimentIDA:ComplexPortal
Biological Process regulation of blood pressure1 PublicationIC:ComplexPortal
Biological Process sensory perception of salty taste1 PublicationIC:ComplexPortal
Biological Process sensory perception of sour taste1 PublicationIC:ComplexPortal
Biological Process sodium ion import across plasma membraneManual Assertion Based On ExperimentIDA:ComplexPortal
Biological Process sodium ion transmembrane transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process sodium ion transportManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Cell membrane

Topology

Cytoplasmic: 1-250
Helical: 251-271
Extracellular: 272-694
Helical: 695-715
Cytoplasmic: 716-802