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Mouse Anti-SCYL1 Recombinant Antibody (CBXS-2893) (CBMAB-S5642-CQ)

This product is a mouse antibody that recognizes SCYL1. The antibody CBXS-2893 can be used for immunoassay techniques such as: ELISA, WB.
See all SCYL1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-2893
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Immunogen
Partial recombinant corresponding to aa373-472 from human SCYL1 (AAH09967) with GST tag
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
SCY1 Like Pseudokinase 1
Introduction
This gene encodes a transcriptional regulator belonging to the SCY1-like family of kinase-like proteins. The protein has a divergent N-terminal kinase domain that is thought to be catalytically inactive, and can bind specific DNA sequences through its C-terminal domain. It activates transcription of the telomerase reverse transcriptase and DNA polymerase beta genes. The protein has been localized to the nucleus, and also to the cytoplasm and centrosomes during mitosis. Multiple transcript variants encoding different isoforms have been found for this gene.
Entrez Gene ID
57410
UniProt ID
Q96KG9
Alternative Names
SCY1 Like Pseudokinase 1; Telomerase Regulation-Associated Protein; Teratoma-Associated Tyrosine Kinase; Telomerase Transcriptional Elements-Interacting Factor; Coated Vesicle-Associated Kinase Of 90 KDa; SCY1-Like, Kinase-Like 1; SCY1-Like Protein 1; TRAP; NTKL; GKLP; TAPK; TEIF;
Function
Regulates COPI-mediated retrograde protein traffic at the interface between the Golgi apparatus and the endoplasmic reticulum (PubMed:18556652).
Involved in the maintenance of the Golgi apparatus morphology (PubMed:26581903).
Has no detectable kinase activity in vitro (PubMed:18556652).
Isoform 6 acts as transcriptional activator. It binds to three different types of GC-rich DNA binding sites (box-A, -B and -C) in the beta-polymerase promoter region. It also binds to the TERT promoter region.
Biological Process
Biological Process inflammatory responseIEA:Ensembl
Biological Process neuron developmentIEA:Ensembl
Biological Process protein localizationIEA:Ensembl
Biological Process retrograde vesicle-mediated transport, Golgi to endoplasmic reticulumManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process spinal cord motor neuron differentiationIEA:Ensembl
Cellular Location
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Endoplasmic reticulum-Golgi intermediate compartment
Golgi apparatus, cis-Golgi network
Localized to the Endoplasmic reticulum-Golgi intermediate and cis-Golgi in an ARF1-independent manner.
Isoform 1
Cytoplasm
Cytoplasmic throughout the cell cycle.
Isoform 2
Cytoplasm
Cytoplasmic throughout the cell cycle.
Isoform 3
Cytoplasm
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Cytoplasmic during interphase and centrosomal during mitosis, it localizes to the centrosomes in a microtubule-independent manner.
Isoform 6
Nucleus
Involvement in disease
Spinocerebellar ataxia, autosomal recessive, 21 (SCAR21):
A form of spinocerebellar ataxia, a clinically and genetically heterogeneous group of cerebellar disorders due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCAR21 is characterized by cerebellar atrophy and ataxia with onset in early childhood. Patients also manifest recurrent episodes of liver failure, hepatic fibrosis and a peripheral neuropathy.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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