Human Recombinant SCYL1 protein, GST Tag (V2LY-0526-LY6688)
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Basic Information
Formulations & Storage [For reference only, actual COA shall prevail!]
Target
Involved in the maintenance of the Golgi apparatus morphology (PubMed:26581903).
Has no detectable kinase activity in vitro (PubMed:18556652).
Isoform 6 acts as transcriptional activator. It binds to three different types of GC-rich DNA binding sites (box-A, -B and -C) in the beta-polymerase promoter region. It also binds to the TERT promoter region.
Biological Process neuron developmentIEA:Ensembl
Biological Process protein localizationIEA:Ensembl
Biological Process retrograde vesicle-mediated transport, Golgi to endoplasmic reticulumManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process spinal cord motor neuron differentiationIEA:Ensembl
Endoplasmic reticulum-Golgi intermediate compartment
Golgi apparatus, cis-Golgi network
Localized to the Endoplasmic reticulum-Golgi intermediate and cis-Golgi in an ARF1-independent manner.
Isoform 1
Cytoplasm
Cytoplasmic throughout the cell cycle.
Isoform 2
Cytoplasm
Cytoplasmic throughout the cell cycle.
Isoform 3
Cytoplasm
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Cytoplasmic during interphase and centrosomal during mitosis, it localizes to the centrosomes in a microtubule-independent manner.
Isoform 6
Nucleus
A form of spinocerebellar ataxia, a clinically and genetically heterogeneous group of cerebellar disorders due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCAR21 is characterized by cerebellar atrophy and ataxia with onset in early childhood. Patients also manifest recurrent episodes of liver failure, hepatic fibrosis and a peripheral neuropathy.
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Please try the standard protocols which include: protocols, troubleshooting and guide.
Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols
Custom Antibody Labeling
We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).
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