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Mouse Anti-SDC1 Recombinant Antibody (CBT2845) (V2LY-0625-LY148)


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Tested Data
Mouse Anti-SDC1 Recombinant Antibody (CBT2845) (V2LY-0625-LY148) in WB
Mouse Anti-SDC1 Recombinant Antibody (CBT2845) (V2LY-0625-LY148) in WB
Mouse Anti-SDC1 Recombinant Antibody (CBT2845) (V2LY-0625-LY148) in WB
Mouse Anti-SDC1 Recombinant Antibody (CBT2845) (V2LY-0625-LY148) in WB
Mouse Anti-SDC1 Recombinant Antibody (CBT2845) (V2LY-0625-LY148) in WB
Mouse Anti-SDC1 Recombinant Antibody (CBT2845) (V2LY-0625-LY148) in WB
Mouse Anti-SDC1 Recombinant Antibody (CBT2845) (V2LY-0625-LY148) in IF
Mouse Anti-SDC1 Recombinant Antibody (CBT2845) (V2LY-0625-LY148) in IF
Mouse Anti-SDC1 Recombinant Antibody (CBT2845) (V2LY-0625-LY148) in FC
Mouse Anti-SDC1 Recombinant Antibody (CBT2845) (V2LY-0625-LY148) in FC
Mouse Anti-SDC1 Recombinant Antibody (CBT2845) (V2LY-0625-LY148) in ELISA
Mouse Anti-SDC1 Recombinant Antibody (CBT2845) (V2LY-0625-LY148) in ELISA

Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
CBT2845
Antibody Isotype
IgG1
Application
WB, ICC, FC

Basic Information

Immunogen
Purified recombinant fragment of human SDC1 (AA: 28-171) expressed in E. Coli.
Host Species
Mouse
Specificity
Human, Mouse
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
ICC1:200-1:1,000
FC1:200-1:400
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
Sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Syndecan 1
Entrez Gene ID
6382
Function
Cell surface proteoglycan that bears both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix. Regulates exosome biogenesis in concert with SDCBP and PDCD6IP (PubMed:22660413).
Biological Process
Biological Process canonical Wnt signaling pathwayIEA:Ensembl
Biological Process cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process inflammatory responseIEA:Ensembl
Biological Process myoblast developmentISS:UniProtKB
Biological Process odontogenesisIEA:Ensembl
Biological Process positive regulation of exosomal secretionManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of extracellular exosome assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process receptor-mediated endocytosisIEA:Ensembl
Biological Process response to calcium ionIEA:Ensembl
Biological Process response to cAMPIEA:Ensembl
Biological Process response to glucocorticoidIEA:Ensembl
Biological Process response to hydrogen peroxideIEA:Ensembl
Biological Process response to toxic substanceIEA:Ensembl
Biological Process Sertoli cell developmentIEA:Ensembl
Biological Process striated muscle cell developmentManual Assertion Based On ExperimentIEP:UniProtKB
Biological Process ureteric bud developmentIEA:Ensembl
Biological Process wound healingIEA:Ensembl
Cellular Location
Membrane
Secreted
Secreted, extracellular exosome
Shedding of the ectodomain produces a soluble form.
Topology
Extracellular: 23-254
Helical: 255-275
Cytoplasmic: 276-310
PTM
Shedding is enhanced by a number of factors such as heparanase, thrombin or EGF. Also by stress and wound healing. PMA-mediated shedding is inhibited by TIMP3.
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For research use only. Not intended for any clinical use.

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