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SDC1

The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-1 expression has been detected in several different tumor types. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same protein. [provided by RefSeq, Jul 2008]
Full Name
Syndecan 1
Function
Cell surface proteoglycan that bears both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix. Regulates exosome biogenesis in concert with SDCBP and PDCD6IP (PubMed:22660413).
Biological Process
Biological Process canonical Wnt signaling pathwayIEA:Ensembl
Biological Process cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process inflammatory responseIEA:Ensembl
Biological Process myoblast developmentISS:UniProtKB
Biological Process odontogenesisIEA:Ensembl
Biological Process positive regulation of exosomal secretionManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of extracellular exosome assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process receptor-mediated endocytosisIEA:Ensembl
Biological Process response to calcium ionIEA:Ensembl
Biological Process response to cAMPIEA:Ensembl
Biological Process response to glucocorticoidIEA:Ensembl
Biological Process response to hydrogen peroxideIEA:Ensembl
Biological Process response to toxic substanceIEA:Ensembl
Biological Process Sertoli cell developmentIEA:Ensembl
Biological Process striated muscle cell developmentManual Assertion Based On ExperimentIEP:UniProtKB
Biological Process ureteric bud developmentIEA:Ensembl
Biological Process wound healingIEA:Ensembl
Cellular Location
Membrane
Secreted
Secreted, extracellular exosome
Shedding of the ectodomain produces a soluble form.
Topology
Extracellular: 23-254
Helical: 255-275
Cytoplasmic: 276-310
PTM
Shedding is enhanced by a number of factors such as heparanase, thrombin or EGF. Also by stress and wound healing. PMA-mediated shedding is inhibited by TIMP3.

Anti-SDC1 antibodies

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Mouse Anti-SDC1 Recombinant Antibody (CBWJC-4411) (CBMAB-C5793WJ)

Datasheet SDS
Target: SDC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-4411
Application*: F

Mouse Anti-SDC1 Recombinant Antibody (MI15) (CBMAB-S6429-CQ)

Datasheet SDS
Target: SDC1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: MI15
Application*: F, IH, IF, P

Rat Anti-SDC1 Recombinant Antibody (CBXS-2633) (CBMAB-S5387-CQ)

Datasheet SDS
Target: SDC1
Host: Rat
Specificity: Mouse
Clone: CBXS-2633
Application*: F, IC, IP, WB

Rabbit Anti-SDC1 Recombinant Antibody (CBXS-5404) (CBMAB-S2616-CQ)

Datasheet SDS
Target: SDC1
Host: Rabbit
Specificity: Human
Clone: CBXS-5404
Application*: WB, IP, F

Rabbit Anti-SDC1 Monoclonal Antibody (SP152) (CBMAB-1602-YC)

Datasheet SDS
Target: SDC1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: SP152
Application*: P

Mouse Anti-SDC1 Monoclonal Antibody (1A3H4) (CBMAB-1601-YC)

Datasheet SDS
Target: SDC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: 1A3H4
Application*: P, IC, IF, F, WB

Mouse Anti-SDC1 Monoclonal Antibody (B-A38) (CBMAB-1600-YC)

Datasheet SDS
Target: SDC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: B-A38
Application*: F, FN, IC, IF, C, P, WB

Mouse Anti-SDC1 Recombinant Antibody (CBXC-1819) (CBMAB-C4572-CQ)

Datasheet SDS
Target: SDC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-1819
Application*: E

Mouse Anti-SDC1 Monoclonal Antibody (BA38) (CBMAB-1599-YC)

Datasheet SDS
Target: SDC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: BA38
Application*: IC, IF, C, F, P, FN, WB

Rabbit Anti-SDC1 Monoclonal Antibody (EPR6454) (CBMAB-1598-YC)

Datasheet SDS
Target: SDC1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: EPR6454
Application*: IC, IF, P, WB

Mouse Anti-SDC1 Recombinant Antibody (CBWJC-4412) (CBMAB-C5794WJ)

Datasheet SDS
Target: SDC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-4412
Application*: E

Mouse Anti-SDC1 Recombinant Antibody (CBXS-2526) (CBMAB-S5282-CQ)

Datasheet SDS
Target: SDC1
Host: Mouse
Specificity: Human, Mouse
Clone: CBXS-2526
Application*: E, IC, IH, WB

Mouse Anti-SDC1 Recombinant Antibody (CBXS-2501) (CBMAB-S5258-CQ)

Datasheet SDS
Target: SDC1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXS-2501
Application*: F, IH

Mouse Anti-SDC1 Recombinant Antibody (CBXS-1985) (CBMAB-S4754-CQ)

Datasheet SDS
Target: SDC1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-1985
Application*: F

Rat Anti-SDC1 Recombinant Antibody (CBXS-1770) (CBMAB-S4587-CQ)

Datasheet SDS
Target: SDC1
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBXS-1770
Application*: WB, IP

Rabbit Anti-SDC1 Recombinant Antibody (CBXS-1545) (CBMAB-S4394-CQ)

Datasheet SDS
Target: SDC1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Rat, Human
Clone: CBXS-1545
Application*: WB, P, F

Mouse Anti-SDC1 Recombinant Antibody (CBXS-1154) (CBMAB-S4036-CQ)

Datasheet SDS
Target: SDC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-1154
Application*: E, WB

Rabbit Anti-SDC1 Recombinant Antibody (CBXS-1056) (CBMAB-S3947-CQ)

Datasheet SDS
Target: SDC1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBXS-1056
Application*: E

Mouse Anti-SDC1 Recombinant Antibody (CBXS-0161) (CBMAB-S3148-CQ)

Datasheet SDS
Target: SDC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-0161
Application*: P, C, F

Rat Anti-SDC1 (AA 18-251) Recombinant Antibody (CBXS-0160) (CBMAB-S3147-CQ)

Datasheet SDS
Target: SDC1
Host: Rat
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-0160
Application*: E, F, IH

Mouse Anti-SDC1 Recombinant Antibody (CBXS-4247) (CBMAB-S1499-CQ)

Datasheet SDS
Target: SDC1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBXS-4247
Application*: E, WB

Mouse Anti-SDC1 Recombinant Antibody (CBXS-3886) (CBMAB-S1155-CQ)

Datasheet SDS
Target: SDC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-3886
Application*: E, WB

Mouse Anti-SDC1 Recombinant Antibody (CBXS-5705) (CBMAB-S0573-CQ)

Datasheet SDS
Target: SDC1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXS-5705
Application*: E, WB, IH

Mouse Anti-SDC1 Recombinant Antibody (CBXS-5659) (CBMAB-S0260-CQ)

Datasheet SDS
Target: SDC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-5659
Application*: E, F, IC, IF, WB

Mouse Anti-SDC1 Recombinant Antibody (V92-P3D9/E7) (CBMAB-S0192-CQ)

Datasheet SDS
Target: SDC1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: V92-P3D9/E7
Application*: WB, E, IH

Mouse Anti-SDC1 Recombinant Antibody (DL-101) (CBMAB-S0185-CQ)

Datasheet SDS
Target: SDC1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: DL-101
Application*: F, C, P

Rat Anti-SDC1 Recombinant Antibody (CBXS-1796) (CBMAB-S0115-CQ)

Datasheet SDS
Target: SDC1
Host: Rat
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-1796
Application*: F

Rat Anti-SDC1 Recombinant Antibody (CBXS-1756) (CBMAB-S0108-CQ)

Datasheet SDS
Target: SDC1
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBXS-1756
Application*: F

Human Anti-SDC1 Recombinant Antibody (CBXC-0706) (CBMAB-C1819-CQ)

Datasheet SDS
Target: SDC1
Host: Human
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBXC-0706
Application*: F

Mouse Anti-SDC1 Recombinant Antibody (CBFYC-3093) (CBMAB-C3170-FY)

Datasheet SDS
Target: SDC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-3093
Application*: F

Rat Anti-SDC1 Recombinant Antibody (CBFYC-0498) (CBMAB-C0549-FY)

Datasheet SDS
Target: SDC1
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: CBFYC-0498
Application*: F, IH, IF

Mouse Anti-SDC1 Recombinant Antibody (SB55a) (CBMAB-S6548-CQ)

Datasheet SDS
Target: SDC1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: SB55a
Application*: F, IH, P, C

Rat Anti-SDC1 Recombinant Antibody (281-2) (CBMAB-C0785-LY)

Datasheet SDS
Target: SDC1
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: 281-2
Application*: F, C

Mouse Anti-SDC1 Recombinant Antibody (480CT5.4.3) (CBMAB-C6520-LY)

Datasheet SDS
Target: SDC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 480CT5.4.3
Application*: WB, E

Mouse Anti-SDC1 Recombinant Antibody (531CT15.4.1;531CT15.1.4) (CBMAB-C7158-LY)

Datasheet SDS
Target: SDC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 531CT15.4.1;531CT15.1.4
Application*: WB

Mouse Anti-SDC1 Recombinant Antibody (5G71) (CBMAB-C7688-LY)

Datasheet SDS
Target: SDC1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 5G71
Application*: E, IH, IP, WB

Mouse Anti-SDC1 Recombinant Antibody (6A372) (CBMAB-C8019-LY)

Datasheet SDS
Target: SDC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 6A372
Application*: E, F, IH

Rat Anti-SDC1 Recombinant Antibody (7H32) (CBMAB-C8845-LY)

Datasheet SDS
Target: SDC1
Host: Rat
Antibody Isotype: IgG1
Specificity: Human
Clone: 7H32
Application*: E, F, IH

Mouse Anti-SDC1 Recombinant Antibody (CBYY-C0232) (CBMAB-C0674-YY)

Datasheet SDS
Target: SDC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C0232
Application*: F

Rat Anti-SDC1 Recombinant Antibody (CBYY-C0662) (CBMAB-C1955-YY)

Datasheet SDS
Target: SDC1
Host: Rat
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C0662
Application*: E, F, IH

Rat Anti-SDC1 Recombinant Antibody (CBYY-C1164) (CBMAB-C2601-YY)

Datasheet SDS
Target: SDC1
Host: Rat
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C1164
Application*: F

Mouse Anti-SDC1 Recombinant Antibody (CBYY-C1165) (CBMAB-C2602-YY)

Datasheet SDS
Target: SDC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C1165
Application*: WB, E

Mouse Anti-SDC1 Recombinant Antibody (CBYY-C1166) (CBMAB-C2603-YY)

Datasheet SDS
Target: SDC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C1166
Application*: WB

Mouse Anti-SDC1 Recombinant Antibody (CBYY-C1167) (CBMAB-C2604-YY)

Datasheet SDS
Target: SDC1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYY-C1167
Application*: E, IH, IP, WB

Mouse Anti-SDC1 Recombinant Antibody (CBYY-C1168) (CBMAB-C2605-YY)

Datasheet SDS
Target: SDC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C1168
Application*: E, F, IH

Recombinant Mouse Anti-SDC1 Recombinant Antibody (V92-P3D9) (CBMAB-XB1029-YC)

Datasheet SDS
Target: SDC1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: V92-P3D9
Application*: E, IH, WB

Mouse Anti-SDC1 Recombinant Antibody (531CT15.4.1) (CBMAB-C4237-CN)

Datasheet SDS
Target: SDC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 531CT15.4.1
Application*: E, WB

Mouse Anti-SDC1 Recombinant Antibody (1B4F4) (CBMAB-R4271-CN)

Datasheet SDS
Target: SDC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: 1B4F4
Application*: E

Mouse Anti-SDC1 Recombinant Antibody (3A2C8) (CBMAB-R4279-CN)

Datasheet SDS
Target: SDC1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 3A2C8
Application*: E

Mouse Anti-SDC1 Recombinant Antibody (1D4) (CBMAB-C12373-LY)

Datasheet SDS
Target: SDC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1D4
Application*: F

Rabbit Anti-SDC1 Recombinant Antibody (D4Y7H) (CBMAB-CP2373-LY)

Datasheet SDS
Target: SDC1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: D4Y7H
Application*: WB, IP, F

Mouse Anti-SDC1 Recombinant Antibody (IHC138) (CBMAB-MA218-YC)

Datasheet SDS
Target: SDC1
Host: Mouse
Specificity: Human
Clone: IHC138
Application*: IH

Mouse Anti-SDC1 Recombinant Antibody (CB318A) (CBMAB-CA318LY)

Datasheet SDS
Target: SDC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: CB318A
Application*: ELISA

Mouse Anti-SDC1 Recombinant Antibody (CB320A) (CBMAB-CA320LY)

Datasheet SDS
Target: SDC1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CB320A
Application*: ELISA

Mouse Anti-SDC1 Recombinant Antibody (CBXC-2886) (CBMAB-C1675-CQ)

Datasheet SDS
Target: SDC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-2886
Application*: F

Mouse Anti-SDC1 Recombinant Antibody (CF383) (CBMAB-FT397LY)

Datasheet SDS
Target: SDC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CF383
Application*: ELISA, WB

Mouse Anti-SDC1 Recombinant Antibody (CF384) (CBMAB-FT399LY)

Datasheet SDS
Target: SDC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CF384
Application*: ELISA, WB, IHC
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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