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Mouse Anti-SEC14L2 Recombinant Antibody (CBXS-4543) (CBMAB-S1783-CQ)

This product is a mouse antibody that recognizes SEC14L2. The antibody CBXS-4543 can be used for immunoassay techniques such as: ELISA, ICC, IF, WB.
See all SEC14L2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-4543
Antibody Isotype
IgG2a, κ
Application
ELISA, ICC, IF, WB

Basic Information

Immunogen
SEC14L2 (NP_036561.1, 101 a.a.-199 a.a) partial recombinant protein with GST tag
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
SEC14-like 2 (S. cerevisiae)
Introduction
This gene encodes a cytosolic protein which belongs to a family of lipid-binding proteins including Sec14p, alpha-tocopherol transfer protein, and cellular retinol-binding protein. The encoded protein stimulates squalene monooxygenase which is a downstream enzyme in the cholesterol biosynthetic pathway. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
Entrez Gene ID
23541
UniProt ID
O76054
Alternative Names
SEC14 Like Lipid Binding 2; Supernatant Protein Factor; Alpha-Tocopherol-Associated Protein; Tocopherol-Associated Protein 1; Squalene Transfer Protein; C22orf6; TAP; SPF; SEC14 (S. Cerevisiae)-Like 2;
Function
Carrier protein. Binds to some hydrophobic molecules and promotes their transfer between the different cellular sites. Binds with high affinity to alpha-tocopherol. Also binds with a weaker affinity to other tocopherols and to tocotrienols. May have a transcriptional activatory activity via its association with alpha-tocopherol. Probably recognizes and binds some squalene structure, suggesting that it may regulate cholesterol biosynthesis by increasing the transfer of squalene to a metabolic active pool in the cell.
Biological Process
Biological Process positive regulation of DNA-templated transcription1 PublicationNAS:UniProtKB
Biological Process regulation of cholesterol biosynthetic process1 PublicationNAS:UniProtKB
Cellular Location
Cytoplasm
Nucleus
Cytoplasmic in absence of alpha-tocopherol, and nuclear in presence of alpha-tocopherol.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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