SEC14L2

This gene encodes a cytosolic protein which belongs to a family of lipid-binding proteins including Sec14p, alpha-tocopherol transfer protein, and cellular retinol-binding protein. The encoded protein stimulates squalene monooxygenase which is a downstream enzyme in the cholesterol biosynthetic pathway. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq]

SEC14-like 2 (S. cerevisiae)

Carrier protein. Binds to some hydrophobic molecules and promotes their transfer between the different cellular sites. Binds with high affinity to alpha-tocopherol. Also binds with a weaker affinity to other tocopherols and to tocotrienols. May have a transcriptional activatory activity via its association with alpha-tocopherol. Probably recognizes and binds some squalene structure, suggesting that it may regulate cholesterol biosynthesis by increasing the transfer of squalene to a metabolic active pool in the cell.

Biological Process positive regulation of DNA-templated transcription1 PublicationNAS:UniProtKB
Biological Process regulation of cholesterol biosynthetic process1 PublicationNAS:UniProtKB

Cytoplasm
Nucleus
Cytoplasmic in absence of alpha-tocopherol, and nuclear in presence of alpha-tocopherol.