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SEC14L2

This gene encodes a cytosolic protein which belongs to a family of lipid-binding proteins including Sec14p, alpha-tocopherol transfer protein, and cellular retinol-binding protein. The encoded protein stimulates squalene monooxygenase which is a downstream enzyme in the cholesterol biosynthetic pathway. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq]
Full Name
SEC14-like 2 (S. cerevisiae)
Function
Carrier protein. Binds to some hydrophobic molecules and promotes their transfer between the different cellular sites. Binds with high affinity to alpha-tocopherol. Also binds with a weaker affinity to other tocopherols and to tocotrienols. May have a transcriptional activatory activity via its association with alpha-tocopherol. Probably recognizes and binds some squalene structure, suggesting that it may regulate cholesterol biosynthesis by increasing the transfer of squalene to a metabolic active pool in the cell.
Biological Process
Biological Process positive regulation of DNA-templated transcription1 PublicationNAS:UniProtKB
Biological Process regulation of cholesterol biosynthetic process1 PublicationNAS:UniProtKB
Cellular Location
Cytoplasm
Nucleus
Cytoplasmic in absence of alpha-tocopherol, and nuclear in presence of alpha-tocopherol.
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Anti-SEC14L2 antibodies

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Mouse Anti-SEC14L2 Recombinant Antibody (2E5) (CBMAB-A7953-LY)

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Target: SEC14L2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2E5
Application*: WB, E
Datasheet SDS

Rabbit Anti-SEC14L2 Recombinant Antibody (CBXS-1610) (CBMAB-S4459-CQ)

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Target: SEC14L2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Rat, Human
Clone: CBXS-1610
Application*: WB, IP, P, IF
Datasheet SDS

Mouse Anti-SEC14L2 Recombinant Antibody (CBXS-5103) (CBMAB-S2321-CQ)

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Target: SEC14L2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Dog
Clone: CBXS-5103
Application*: WB, F, IH, IF, P
Datasheet SDS

Mouse Anti-SEC14L2 Recombinant Antibody (CBXS-4610) (CBMAB-S1850-CQ)

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Target: SEC14L2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-4610
Application*: WB
Datasheet SDS

Mouse Anti-SEC14L2 Recombinant Antibody (CBXS-4543) (CBMAB-S1783-CQ)

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Target: SEC14L2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXS-4543
Application*: E, IC, IF, WB
Datasheet SDS

Mouse Anti-SEC14L2 Recombinant Antibody (CBXS-4214) (CBMAB-S1467-CQ)

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Target: SEC14L2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-4214
Application*: IF, WB
Datasheet SDS

Mouse Anti-SEC14L2 Recombinant Antibody (CBXS-4092) (CBMAB-S1349-CQ)

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Target: SEC14L2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4092
Application*: F, IF, P, WB
Datasheet SDS

Mouse Anti-SEC14L2 Recombinant Antibody (CBXS-3849) (CBMAB-S1119-CQ)

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Target: SEC14L2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-3849
Application*: WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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