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Rabbit Anti-SEC61B Recombinant Antibody (CBXS-0185) (CBMAB-S3171-CQ)

This product is a rabbit antibody that recognizes SEC61B. The antibody CBXS-0185 can be used for immunoassay techniques such as: WB, IP.
See all SEC61B antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat, Monkey
Clone
CBXS-0185
Antibody Isotype
IgG
Application
WB, IP

Basic Information

Specificity
Human, Mouse, Rat, Monkey
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Sec61 Translocon Beta Subunit
Introduction
The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. Oligomers of the Sec61 complex form a transmembrane channel where proteins are translocated across and integrated into the ER membrane. This complex consists of three membrane proteins- alpha, beta, and gamma. This gene encodes the beta-subunit protein. The Sec61 subunits are also observed in the post-ER compartment, suggesting that these proteins can escape the ER and recycle back. There is evidence for multiple polyadenylated sites for this transcript.
Entrez Gene ID
Human10952
Mouse66212
Rat298068
Monkey717815
UniProt ID
HumanP60468
MouseQ9CQS8
RatB2RZD1
MonkeyF7B5P3
Alternative Names
Sec61 Translocon Beta Subunit; Sec61 Beta Subunit;
Function
Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across the endoplasmic reticulum (ER) (PubMed:12475939).
Component of a ribosome-associated ER translocon complex involved in multi-pass membrane protein transport into the ER membrane and biogenesis (PubMed:32820719).
The SEC61 channel cooperates with the translocating protein TRAM1 to import nascent proteins into the ER (PubMed:19121997).
Required for PKD1/Polycystin-1 biogenesis (By similarity).
Biological Process
Biological Process post-translational protein targeting to membrane, translocationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process retrograde protein transport, ER to cytosolManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process SRP-dependent cotranslational protein targeting to membrane, translocationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process ubiquitin-dependent ERAD pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Endoplasmic reticulum membrane
Involvement in disease
Loss-of-function SEC61B variations may cause autosomal dominant polycystic liver disease (PCLD) in patients that lack variations in known causative genes, such as PRKCSH and SEC63.
Topology
Cytoplasmic: 2-70
Helical: 71-91
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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