Rabbit Anti-SEC61B Recombinant Antibody (CBXS-5411) (CBMAB-S2623-CQ)

Name: Rabbit Anti-SEC61B Recombinant Antibody (CBXS-5411)
SKU: CBMAB-S2623-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Rabbit

Clone

CBXS-5411

Application

IP, WB

Immunogen

Synthetic peptide corresponding to residues surrounding Gly12 of human Sec61B

Specificity

Human, Monkey, Mouse, Rat

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

10 mM sodium HEPES, pH 7.5, 0.1 mg/mL BSA, 150 mM sodium chloride, 50% glycerol

Preservative

0.02% sodium azide

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Sec61 Translocon Beta Subunit

Introduction

The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. Oligomers of the Sec61 complex form a transmembrane channel where proteins are translocated across and integrated into the ER membrane. This complex consists of three membrane proteins- alpha, beta, and gamma. This gene encodes the beta-subunit protein. The Sec61 subunits are also observed in the post-ER compartment, suggesting that these proteins can escape the ER and recycle back. There is evidence for multiple polyadenylated sites for this transcript.

Entrez Gene ID

Human	10952
Mouse	66212
Rat	298068
Monkey	717815

UniProt ID

Human	P60468
Mouse	Q9CQS8
Rat	B2RZD1
Monkey	F7B5P3

Alternative Names

Sec61 Translocon Beta Subunit; Sec61 Beta Subunit;

Function

Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across the endoplasmic reticulum (ER) (PubMed:12475939).
Component of a ribosome-associated ER translocon complex involved in multi-pass membrane protein transport into the ER membrane and biogenesis (PubMed:32820719).
The SEC61 channel cooperates with the translocating protein TRAM1 to import nascent proteins into the ER (PubMed:19121997).
Required for PKD1/Polycystin-1 biogenesis (By similarity).

Biological Process

Biological Process post-translational protein targeting to membrane, translocationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process retrograde protein transport, ER to cytosolManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process SRP-dependent cotranslational protein targeting to membrane, translocationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process ubiquitin-dependent ERAD pathwayManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Endoplasmic reticulum membrane

Involvement in disease

Loss-of-function SEC61B variations may cause autosomal dominant polycystic liver disease (PCLD) in patients that lack variations in known causative genes, such as PRKCSH and SEC63.

Topology

Cytoplasmic: 2-70
Helical: 71-91

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

Rabbit Anti-SEC61B Recombinant Antibody (CBXS-0185) (CAT#: CBMAB-S3171-CQ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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