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Mouse Anti-SEC63 Recombinant Antibody (CBXS-3841) (CBMAB-S1111-CQ)

This product is a mouse antibody that recognizes SEC63. The antibody CBXS-3841 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all SEC63 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-3841
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
SEC63 homolog (S. cerevisiae)
Introduction
The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The protein encoded by this gene and SEC62 protein are found to be associated with ribosome-free SEC61 complex. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. The encoded protein is an integral membrane protein located in the rough ER.
Entrez Gene ID
11231
UniProt ID
Q9UGP8
Alternative Names
SEC63 Homolog, Protein Translocation Regulator; SEC63L; SEC63 Protein Translocation Regulator; Translocation Protein SEC63 Homolog; SEC63 Homolog (S. Cerevisiae); SEC63-Like (S. Cerevisiae);
Function
Mediates cotranslational and post-translational transport of certain precursor polypeptides across endoplasmic reticulum (ER) (PubMed:22375059, PubMed:29719251).
Proposed to play an auxiliary role in recognition of precursors with short and apolar signal peptides. May cooperate with SEC62 and HSPA5/BiP to facilitate targeting of small presecretory proteins into the SEC61 channel-forming translocon complex, triggering channel opening for polypeptide translocation to the ER lumen (PubMed:29719251).
Required for efficient PKD1/Polycystin-1 biogenesis and trafficking to the plasma membrane of the primary cilia (By similarity).
Biological Process
Biological Process liver developmentIEA:Ensembl
Biological Process multicellular organism agingIEA:Ensembl
Biological Process nitrogen compound metabolic processIEA:Ensembl
Biological Process post-translational protein targeting to endoplasmic reticulum membraneManual Assertion Based On ExperimentIMP:MGI
Biological Process post-translational protein targeting to membrane, translocationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process protein targeting to membraneManual Assertion Based On ExperimentTAS:ProtInc
Biological Process SRP-dependent cotranslational protein targeting to membraneManual Assertion Based On ExperimentIMP:MGI
Cellular Location
Endoplasmic reticulum membrane
Involvement in disease
Polycystic liver disease 2 with or without kidney cysts (PCLD2):
An autosomal dominant hepatobiliary disease characterized by overgrowth of biliary epithelium and supportive connective tissue, resulting in multiple liver cysts. A subset of patients may develop kidney cysts that usually do not result in clinically significant renal disease.
Topology
Lumenal: 1-14
Helical: 15-35
Cytoplasmic: 36-69
Helical: 70-90
Lumenal: 91-188
Helical: 189-209
Cytoplasmic: 210-760
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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