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Mouse Anti-SELL Recombinant Antibody (DREG56) (CBMAB-L0397-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to Selectin L (SELL). The antibody can be used for immunoassay techniques, such as FC.
See all SELL antibodies
Published Data
Fig.1 CD62L on neutrophils in male and female healthy volunteers at baseline, 8 hours, and 32 hours following typhoid vaccine administration.
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Fig.2 CD62L was measured using flow cytometry.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
DREG56
Antibody Isotype
IgG1, κ
Application
FC

Basic Information

Immunogen
Supernatant from PMA-activated human peripheral blood leukocytes.
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.2, 0.2% BSA
Preservative
0.09% Sodium Azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Selectin L
Introduction
SELL is a cell surface adhesion molecule that belongs to a family of adhesion/homing receptors. SELL has a C-type lectin-like domain, a calcium-binding epidermal growth factor-like domain, and two short complement-like repeats. SELL is required for binding and subsequent rolling of leucocytes on endothelial cells, facilitating their migration into secondary lymphoid organs and inflammation sites. Single-nucleotide polymorphisms in this gene have been involved in various diseases including immunoglobulin A nephropathy. It has beeen found alternatively spliced transcript variants for this gene.
Entrez Gene ID
6402
UniProt ID
P14151
Alternative Names
Selectin L; Leukocyte-Endothelial Cell Adhesion Molecule 1; CD62 Antigen-Like Family Member L; Leukocyte Surface Antigen Leu-8; Lymphocyte Adhesion Molecule 1; Lymph Node Homing Receptor; Gp90-MEL; LECAM1; LYAM1; LNHR; TQ1
Function
Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells (PubMed:12403782, PubMed:28489325, PubMed:28011641).
Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia (PubMed:12403782, PubMed:28011641).
Biological Process
Biological Process calcium-dependent cell-cell adhesion via plasma membrane cell adhesion moleculesManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process cell adhesionManual Assertion Based On ExperimentTAS:ProtInc
Biological Process leukocyte cell-cell adhesionManual Assertion Based On ExperimentTAS:BHF-UCL
Biological Process leukocyte tethering or rollingManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Cell membrane
Topology
Extracellular: 39-332
Helical: 333-355
Cytoplasmic: 356-372
PTM
N-glycosylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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