SELL
This gene encodes a cell surface adhesion molecule that belongs to a family of adhesion/homing receptors. The encoded protein contains a C-type lectin-like domain, a calcium-binding epidermal growth factor-like domain, and two short complement-like repeats. The gene product is required for binding and subsequent rolling of leucocytes on endothelial cells, facilitating their migration into secondary lymphoid organs and inflammation sites. Single-nucleotide polymorphisms in this gene have been associated with various diseases including immunoglobulin A nephropathy. Alternatively spliced transcript variants have been found for this gene.
Full Name
Selectin L
Alternative Names
Selectin L; Leukocyte-Endothelial Cell Adhesion Molecule 1; CD62 Antigen-Like Family Member L; Leukocyte Surface Antigen Leu-8; Lymphocyte Adhesion Molecule 1; Lymph Node Homing Receptor; Gp90-MEL; LECAM1; LYAM1; LNHR; TQ1;
Function
Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells (PubMed:12403782, PubMed:28489325, PubMed:28011641).
Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia (PubMed:12403782, PubMed:28011641).
Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia (PubMed:12403782, PubMed:28011641).
Biological Process
Biological Process calcium-dependent cell-cell adhesion via plasma membrane cell adhesion moleculesManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process cell adhesionManual Assertion Based On ExperimentTAS:ProtInc
Biological Process leukocyte cell-cell adhesionManual Assertion Based On ExperimentTAS:BHF-UCL
Biological Process leukocyte tethering or rollingManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process cell adhesionManual Assertion Based On ExperimentTAS:ProtInc
Biological Process leukocyte cell-cell adhesionManual Assertion Based On ExperimentTAS:BHF-UCL
Biological Process leukocyte tethering or rollingManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Cell membrane
Topology
Extracellular: 39-332
Helical: 333-355
Cytoplasmic: 356-372
Helical: 333-355
Cytoplasmic: 356-372
PTM
N-glycosylated.
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Anti-SELL antibodies
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CompareTarget: SELL
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 122
Application*: F
Target: SELL
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Cattle, Dog, Monkey
Clone: CBYJL-280
Application*: WB, IF, IP, F
Target: SELL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: AG168
Application*: B, F, IF, C, WB
Target: SELL
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: AG169
Application*: B, MC, F, C, IP, WB
Target: SELL
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: A1422
Application*: F, MC, C, IP
Target: SELL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Sheep, Cattle
Clone: 13
Application*: F
Target: SELL
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Chimpanzee, Cattle
Clone: 62
Application*: WB, F, B
Target: SELL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 46
Application*: E, IF
Target: SELL
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 85
Application*: IF, F
Target: SELL
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYC-3100
Application*: E
Target: SELL
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Mouse, Rat
Clone: CBFYC-0169
Application*: F
Target: SELL
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: 023
Application*: IF, F
Target: SELL
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: 74
Application*: WB, IF, IP, P, E
Target: SELL
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYJL-2475
Application*: IF, F
Target: SELL
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat, Guinea pig
Clone: CBYJL-278
Application*: WB, IF, IP, F
Target: SELL
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Cattle, Dog, Monkey
Clone: CBYJL-277
Application*: WB, IF, IP, F
Target: SELL
Sensitivity: 0.175 ng/mL
Detection Range: 0.3-90 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Target: SELL
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-332
Tag: His Tag
Target: SELL
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-332
Tag: His Tag
Target: SELL
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-332
Tag: His & hFc Tag
Target: SELL
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-332
Tag: His Tag
Target: SELL
Expressed Host: CHO Cells
Sequence: Amino Acid: 1-332
Tag: His Tag
Target: SELL
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-332
Tag: His Tag
Target: SELL
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-332
Tag: hFc Tag
Target: SELL
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBT4445
Application*: IH, F
Target: SELL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT4497
Application*: IC
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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