SELL
This gene encodes a cell surface adhesion molecule that belongs to a family of adhesion/homing receptors. The encoded protein contains a C-type lectin-like domain, a calcium-binding epidermal growth factor-like domain, and two short complement-like repeats. The gene product is required for binding and subsequent rolling of leucocytes on endothelial cells, facilitating their migration into secondary lymphoid organs and inflammation sites. Single-nucleotide polymorphisms in this gene have been associated with various diseases including immunoglobulin A nephropathy. Alternatively spliced transcript variants have been found for this gene.
Full Name
Selectin L
Alternative Names
Selectin L; Leukocyte-Endothelial Cell Adhesion Molecule 1; CD62 Antigen-Like Family Member L; Leukocyte Surface Antigen Leu-8; Lymphocyte Adhesion Molecule 1; Lymph Node Homing Receptor; Gp90-MEL; LECAM1; LYAM1; LNHR; TQ1;
Function
Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells (PubMed:12403782, PubMed:28489325, PubMed:28011641).
Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia (PubMed:12403782, PubMed:28011641).
Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia (PubMed:12403782, PubMed:28011641).
Biological Process
Biological Process calcium-dependent cell-cell adhesion via plasma membrane cell adhesion moleculesManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process cell adhesionManual Assertion Based On ExperimentTAS:ProtInc
Biological Process leukocyte cell-cell adhesionManual Assertion Based On ExperimentTAS:BHF-UCL
Biological Process leukocyte tethering or rollingManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process cell adhesionManual Assertion Based On ExperimentTAS:ProtInc
Biological Process leukocyte cell-cell adhesionManual Assertion Based On ExperimentTAS:BHF-UCL
Biological Process leukocyte tethering or rollingManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Cell membrane
Topology
Extracellular: 39-332
Helical: 333-355
Cytoplasmic: 356-372
Helical: 333-355
Cytoplasmic: 356-372
PTM
N-glycosylated.
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Anti-SELL antibodies
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CompareTarget: SELL
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: HI62L
Application*: E, WB
Target: SELL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 6D41
Application*: E, FC, IH
Target: SELL
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXS-4215
Application*: F
Target: SELL
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: 122
Application*: P
Target: SELL
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Cattle, Dog
Clone: CBYJL-280
Application*: F, IH, C
Target: SELL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: AG168
Application*: B, F, IF, C, WB
Target: SELL
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: AG169
Application*: B, MC, F, C, IP, WB
Target: SELL
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: A1423
Application*: FC, IHC, IP
Target: SELL
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: A1422
Application*: FC, IHC, IP
Target: SELL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: A1421
Application*: FC, WB
Target: SELL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CB358
Application*: IF, FC
Target: SELL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CB357
Application*: IF, FC
Target: SELL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CB356
Application*: IF, FC
Target: SELL
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: MAB0824
Application*: F
Target: SELL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: 3H1613
Application*: F
Target: SELL
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Baboon, Chimpanzee, Monkey, Human
Clone: SK11
Application*: F
Target: SELL
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 5F51
Application*: FC, IF
Target: SELL
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 13A163
Application*: FC
Target: SELL
Host: Sheep
Specificity: Human
Clone: 12G4
Application*: E, DB, IH, WB
Target: SELL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-4423
Application*: F, IH
Target: SELL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-4422
Application*: F
Target: SELL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-4421
Application*: E, F, FN, WB
Target: SELL
Host: Armenian Hamster
Antibody Isotype: IgG2, λ
Specificity: Rat
Clone: CBWJC-2397
Application*: F
Target: SELL
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBWJC-2396
Application*: E, F
Target: SELL
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: DREG-56
Application*: F, FN, C, N, WB
Target: SELL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-2395
Application*: E, F, P
Target: SELL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: B-S13
Application*: E, F
Target: SELL
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: HI62L
Application*: E, F
Target: SELL
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: FMC46
Application*: F, C, IP
Target: SELL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Cattle
Clone: CC32
Application*: F
Target: SELL
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: CBXS-5483
Application*: F, IH, IP
Target: SELL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-5928
Application*: E, WB, IF
Target: SELL
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: LAM1-116
Application*: F, FN
Target: SELL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: OX-85
Application*: F
Target: SELL
Host: Human
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-0898
Application*: F
Target: SELL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-1859
Application*: F, E
Target: SELL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: LT-TD180
Application*: F
Target: SELL
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBXC-1477
Application*: F, IP, WB
Target: SELL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-2416
Application*: F
Target: SELL
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBFYC-3100
Application*: P
Target: SELL
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBFYC-3099
Application*: F, IH
Target: SELL
Host: Sheep
Specificity: Human
Clone: CBFYC-3098
Application*: E, DB, IH, WB
Target: SELL
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYC-0409
Application*: FN, F
Target: SELL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Cattle
Clone: CBFYC-0169
Application*: F
Target: SELL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-0080
Application*: F
Target: SELL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-0067
Application*: E, F
Target: SELL
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: 023
Application*: E, EC
Target: SELL
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: 414
Application*: IC/IF, IF
Target: SELL
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Cattle, Human, Monkey
Clone: 3H1611
Application*: F, IH, IP
Target: SELL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Cattle
Clone: 10B1874
Application*: F
Target: SELL
Host: Sheep
Antibody Isotype: IgG
Specificity: Human
Clone: CBYCL-633
Application*: E, WB, DB, IH
Target: SELL
Host: Rat
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBYCL-632
Application*: F, C, IP, BL
Target: SELL
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Rat
Clone: CBYJL-2475
Application*: FC
Target: SELL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: CBYJL-2474
Application*: WB, EC
Target: SELL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Cattle
Clone: IVA94
Application*: FC
Target: SELL
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: MEL-14
Application*: FC
Target: SELL
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: MAB0709
Application*: P, FC
Target: SELL
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: AP-MAB0709
Application*: FC, P
Target: SELL
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBYJL-2402
Application*: FC
Target: SELL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJL-281
Application*: F
Target: SELL
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: DREG56
Application*: F
Target: SELL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJL-278
Application*: WB, F, E, IH
Target: SELL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJL-277
Application*: F
Target: SELL
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBT4445
Application*: IH, F
Target: SELL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT4497
Application*: IC
Target: SELL
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 7H203
Application*: F
Target: SELL
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 18
Application*: E
Target: SELL
Host: sheep
Antibody Isotype: IgG
Specificity: Human
Clone: 12G5
Application*: E, DB, C, WB
Target: SELL
Host: sheep
Antibody Isotype: IgG
Specificity: Human
Clone: 12G3
Application*: E, DB, C, WB
Target: SELL
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 037
Application*: EC
Target: SELL
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 018
Application*: E, ED
Target: SELL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 01
Application*: E, F
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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