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Mouse Anti-SEMA3E Recombinant Antibody (CBXS-1816) (CBMAB-S0121-CQ)

This product is a mouse antibody that recognizes SEMA3E. The antibody CBXS-1816 can be used for immunoassay techniques such as: ICFC.
See all SEMA3E antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-1816
Antibody Isotype
IgG1
Application
ICFC

Basic Information

Immunogen
NS0-derived recombinant human Semaphorin 3E, Thr25-Ser775 (Arg557Ala and Arg560Ala), Accession # O15041
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
A saline solution, BSA
Preservative
Sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Semaphorin 3E
Introduction
Semaphorins are a large family of conserved secreted and membrane associated proteins which possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Based on sequence and structural similarities, semaphorins are put into eight classes: invertebrates contain classes 1 and 2, viruses have class V, and vertebrates contain classes 3-7. Semaphorins serve as axon guidance ligands via multimeric receptor complexes, some (if not all) containing plexin proteins. This gene encodes a class 4 semaphorin. This gene encodes a class 3 semaphorin. Multiple transcript variants encoding different isoforms have been found for this gene.
Entrez Gene ID
9723
UniProt ID
O15041
Alternative Names
Semaphorin 3E; Sema Domain, Immunoglobulin Domain (Ig), Short Basic Domain, Secreted, (Semaphorin) 3E; SEMAH; Semaphorin-3E; M-Sema H; KIAA0331; M-SEMAH; M-SemaK; Coll-5;
Function
Plays an important role in signaling via the cell surface receptor PLXND1. Mediates reorganization of the actin cytoskeleton, leading to the retraction of cell projections. Promotes focal adhesion disassembly and inhibits adhesion of endothelial cells to the extracellular matrix. Regulates angiogenesis, both during embryogenesis and after birth. Can down-regulate sprouting angiogenesis. Required for normal vascular patterning during embryogenesis. Plays an important role in ensuring the specificity of synapse formation (By similarity).
Biological Process
Biological Process axon guidanceManual Assertion Based On ExperimentIBA:GO_Central
Biological Process branching involved in blood vessel morphogenesisISS:UniProtKB
Biological Process gonadotrophin-releasing hormone neuronal migration to the hypothalamusManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process negative chemotaxisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of angiogenesisISS:UniProtKB
Biological Process negative regulation of axon extension involved in axon guidanceManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of cell-matrix adhesionISS:UniProtKB
Biological Process negative regulation of neuron apoptotic processManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process neural crest cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of phosphatidylinositol 3-kinase signalingManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process regulation of actin cytoskeleton reorganizationISS:UniProtKB
Biological Process regulation of cell shapeISS:UniProtKB
Biological Process semaphorin-plexin signaling pathwayManual Assertion Based On ExperimentIGI:ARUK-UCL
Biological Process sprouting angiogenesisISS:UniProtKB
Biological Process synapse organizationISS:UniProtKB
Cellular Location
Secreted
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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