SEMA3E

Semaphorins are a large family of conserved secreted and membrane associated proteins which possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Based on sequence and structural similarities, semaphorins are put into eight classes: invertebrates contain classes 1 and 2, viruses have class V, and vertebrates contain classes 3-7. Semaphorins serve as axon guidance ligands via multimeric receptor complexes, some (if not all) containing plexin proteins. This gene encodes a class 4 semaphorin. This gene encodes a class 3 semaphorin. Multiple transcript variants encoding different isoforms have been found for this gene.

Full Name

Semaphorin 3E

Function

Plays an important role in signaling via the cell surface receptor PLXND1. Mediates reorganization of the actin cytoskeleton, leading to the retraction of cell projections. Promotes focal adhesion disassembly and inhibits adhesion of endothelial cells to the extracellular matrix. Regulates angiogenesis, both during embryogenesis and after birth. Can down-regulate sprouting angiogenesis. Required for normal vascular patterning during embryogenesis. Plays an important role in ensuring the specificity of synapse formation (By similarity).

Biological Process

Biological Process axon guidanceManual Assertion Based On ExperimentIBA:GO_Central
Biological Process branching involved in blood vessel morphogenesisISS:UniProtKB
Biological Process gonadotrophin-releasing hormone neuronal migration to the hypothalamusManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process negative chemotaxisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of angiogenesisISS:UniProtKB
Biological Process negative regulation of axon extension involved in axon guidanceManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of cell-matrix adhesionISS:UniProtKB
Biological Process negative regulation of neuron apoptotic processManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process neural crest cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of phosphatidylinositol 3-kinase signalingManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process regulation of actin cytoskeleton reorganizationISS:UniProtKB
Biological Process regulation of cell shapeISS:UniProtKB
Biological Process semaphorin-plexin signaling pathwayManual Assertion Based On ExperimentIGI:ARUK-UCL
Biological Process sprouting angiogenesisISS:UniProtKB
Biological Process synapse organizationISS:UniProtKB

Cellular Location

Secreted