Mouse Anti-SENP1 Recombinant Antibody (CBXS-4013) (CBMAB-S1274-CQ)

Name: Mouse Anti-SENP1 Recombinant Antibody (CBXS-4013)
SKU: CBMAB-S1274-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBXS-4013

Application

WB, FC

Immunogen

Human recombinant protein fragment corresponding to amino acids 221-460 of human SENP1 (NP_055369)

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

SUMO1/Sentrin Specific Peptidase 1

Introduction

This gene encodes a cysteine protease that specifically targets members of the small ubiquitin-like modifier (SUMO) protein family. This protease regulates SUMO pathways by deconjugating sumoylated proteins. This protease also functions to process the precursor SUMO proteins into their mature form. Alternate splicing results in multiple transcript variants.

Entrez Gene ID

29843

UniProt ID

Q9P0U3

Alternative Names

SUMO1/Sentrin Specific Peptidase 1; Sentrin/SUMO-Specific Protease SENP1; SUMO1/Sentrin Specific Protease 1; Sentrin-Specific Protease 1; EC 3.4.22.-; EC 3.4.22; SuPr-2;

Function

Protease that catalyzes two essential functions in the SUMO pathway (PubMed:10652325, PubMed:15199155, PubMed:16253240, PubMed:16553580, PubMed:21829689, PubMed:21965678, PubMed:23160374, PubMed:24943844, PubMed:25406032, PubMed:29506078).
The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins. The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein. Deconjugates SUMO1 from HIPK2 (PubMed:16253240).
Deconjugates SUMO1 from HDAC1 and BHLHE40/DEC1, which decreases its transcriptional repression activity (PubMed:21829689).
Deconjugates SUMO1 from CLOCK, which decreases its transcriptional activation activity (PubMed:23160374).
Deconjugates SUMO2 from MTA1 (PubMed:21965678).
Deconjugates SUMO1 from METTL3 (PubMed:29506078).
Desumoylates CCAR2 which decreases its interaction with SIRT1 (PubMed:25406032).
Deconjugates SUMO1 from GPS2 (PubMed:24943844).

Biological Process

Biological Process activation of cysteine-type endopeptidase activity involved in apoptotic processManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process apoptotic signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIGI:MGI
Biological Process protein desumoylationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process proteolysisManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Nucleus
Cytoplasm
Shuttles between cytoplasm and nucleus.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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