Sign in or Register   Sign in or Register
  |  

Mouse Anti-SENP1 Recombinant Antibody (CBXS-4013) (CBMAB-S1274-CQ)

This product is a mouse antibody that recognizes SENP1. The antibody CBXS-4013 can be used for immunoassay techniques such as: WB, FC.
See all SENP1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-4013
Antibody Isotype
IgG1
Application
WB, FC

Basic Information

Immunogen
Human recombinant protein fragment corresponding to amino acids 221-460 of human SENP1 (NP_055369)
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
SUMO1/Sentrin Specific Peptidase 1
Introduction
This gene encodes a cysteine protease that specifically targets members of the small ubiquitin-like modifier (SUMO) protein family. This protease regulates SUMO pathways by deconjugating sumoylated proteins. This protease also functions to process the precursor SUMO proteins into their mature form. Alternate splicing results in multiple transcript variants.
Entrez Gene ID
29843
UniProt ID
Q9P0U3
Alternative Names
SUMO1/Sentrin Specific Peptidase 1; Sentrin/SUMO-Specific Protease SENP1; SUMO1/Sentrin Specific Protease 1; Sentrin-Specific Protease 1; EC 3.4.22.-; EC 3.4.22; SuPr-2;
Function
Protease that catalyzes two essential functions in the SUMO pathway (PubMed:10652325, PubMed:15199155, PubMed:16253240, PubMed:16553580, PubMed:21829689, PubMed:21965678, PubMed:23160374, PubMed:24943844, PubMed:25406032, PubMed:29506078).
The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins. The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein. Deconjugates SUMO1 from HIPK2 (PubMed:16253240).
Deconjugates SUMO1 from HDAC1 and BHLHE40/DEC1, which decreases its transcriptional repression activity (PubMed:21829689).
Deconjugates SUMO1 from CLOCK, which decreases its transcriptional activation activity (PubMed:23160374).
Deconjugates SUMO2 from MTA1 (PubMed:21965678).
Deconjugates SUMO1 from METTL3 (PubMed:29506078).
Desumoylates CCAR2 which decreases its interaction with SIRT1 (PubMed:25406032).
Deconjugates SUMO1 from GPS2 (PubMed:24943844).
Biological Process
Biological Process activation of cysteine-type endopeptidase activity involved in apoptotic processManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process apoptotic signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIGI:MGI
Biological Process protein desumoylationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process proteolysisManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Nucleus
Cytoplasm
Shuttles between cytoplasm and nucleus.
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-SENP1 Recombinant Antibody (CBXS-4013)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare