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Mouse Anti-SENP6 Recombinant Antibody (CBXS-4993) (CBMAB-S2215-CQ)

This product is a mouse antibody that recognizes SENP6. The antibody CBXS-4993 can be used for immunoassay techniques such as: ELISA, IHC-P, WB.
See all SENP6 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-4993
Antibody Isotype
IgG2a, κ
Application
ELISA, IHC-P, WB

Basic Information

Immunogen
Partial recombinant corresponding to aa1-111 from human SENP6 (NP_056386) with GST tag
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
SUMO1/sentrin specific peptidase 6
Introduction
Ubiquitin-like molecules (UBLs), such as SUMO1 (UBL1; MIM 601912), are structurally related to ubiquitin (MIM 191339) and can be ligated to target proteins in a similar manner as ubiquitin. However, covalent attachment of UBLs does not result in degradation of the modified proteins. SUMO1 modification is implicated in the targeting of RANGAP1 (MIM 602362) to the nuclear pore complex, as well as in stabilization of I-kappa-B-alpha (NFKBIA; MIM 164008) from degradation by the 26S proteasome. Like ubiquitin, UBLs are synthesized as precursor proteins, with 1 or more amino acids following the C-terminal glycine-glycine residues of the mature UBL protein. Thus, the tail sequences of the UBL precursors need to be removed by UBL-specific proteases, such as SENP6, prior to their conjugation to target proteins (Kim et al., 2000 [PubMed 10799485]). SENPs also display isopeptidase activity for deconjugation of SUMO-conjugated substrates (Lima and Reverter, 2008 [PubMed 18799455]).
Entrez Gene ID
26054
UniProt ID
Q9GZR1
Alternative Names
SUMO1/Sentrin Specific Peptidase 6; Sentrin/SUMO-Specific Protease SENP6; SUMO1/Sentrin Specific Protease 6; SUMO-1-Specific Protease 1; SUSP1; SSP1;
Function
Protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. Processes preferentially poly-SUMO2 and poly-SUMO3 chains, but does not efficiently process SUMO1, SUMO2 and SUMO3 precursors. Deconjugates SUMO1 from RXRA, leading to transcriptional activation. Involved in chromosome alignment and spindle assembly, by regulating the kinetochore CENPH-CENPI-CENPK complex. Desumoylates PML and CENPI, protecting them from degradation by the ubiquitin ligase RNF4, which targets polysumoylated proteins for proteasomal degradation. Desumoylates also RPA1, thus preventing recruitment of RAD51 to the DNA damage foci to initiate DNA repair through homologous recombination.
Biological Process
Biological Process protein desumoylationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process protein modification by small protein removalManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process protein sumoylationIEA:UniProtKB-UniPathway
Biological Process regulation of kinetochore assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of spindle assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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