Human Recombinant SENP6 , Active protein, His Tag (V2LY-0526-LY6711)

Name: Human Recombinant SENP6 , Active protein, His Tag
SKU: V2LY-0526-LY6711
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

E. coli

Protein Species

Human

Tag

His Tag

Protein Construction

This product is Human Recombinant SENP6 , Active protein, His Tag consist of Amino Acid: 637-1112 and predicts a molecular mass of 64 kDa.

Molecule Mass

64 kDa

Sequence

Amino Acid: 637-1112

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

Batch dependent.

Endotoxin

Please contact us for more information.

Format

Liquid

Buffer

PBS

Preservative

None

Storage

Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

More Infomation

Target

Full Name

SUMO1/sentrin specific peptidase 6

Function

Protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. Processes preferentially poly-SUMO2 and poly-SUMO3 chains, but does not efficiently process SUMO1, SUMO2 and SUMO3 precursors. Deconjugates SUMO1 from RXRA, leading to transcriptional activation. Involved in chromosome alignment and spindle assembly, by regulating the kinetochore CENPH-CENPI-CENPK complex. Desumoylates PML and CENPI, protecting them from degradation by the ubiquitin ligase RNF4, which targets polysumoylated proteins for proteasomal degradation. Desumoylates also RPA1, thus preventing recruitment of RAD51 to the DNA damage foci to initiate DNA repair through homologous recombination.

Biological Process

Biological Process protein desumoylationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process protein modification by small protein removalManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process protein sumoylationIEA:UniProtKB-UniPathway
Biological Process regulation of kinetochore assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of spindle assemblyManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Nucleus

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Mouse Anti-SENP6 Recombinant Antibody (4B7) (CAT#: CBMAB-A7970-LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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