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Mouse Anti-SERPINA3 Recombinant Antibody (CBXS-2708) (CBMAB-S5459-CQ)

This product is a mouse antibody that recognizes SERPINA3. The antibody CBXS-2708 can be used for immunoassay techniques such as: ELISA, IHC.
See all SERPINA3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-2708
Antibody Isotype
IgG2a, κ
Application
ELISA, IHC

Basic Information

Immunogen
Recombinant corresponding to aa25-424 from human SERPINA3 with GST tag
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Concentration
0.1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Serpin Family A Member 3
Introduction
The protein encoded by this gene is a plasma protease inhibitor and member of the serine protease inhibitor class. Polymorphisms in this protein appear to be tissue specific and influence protease targeting. Variations in this protein's sequence have been implicated in Alzheimer's disease, and deficiency of this protein has been associated with liver disease. Mutations have been identified in patients with Parkinson disease and chronic obstructive pulmonary disease.
Entrez Gene ID
12
UniProt ID
P01011
Alternative Names
Serpin Family A Member 3; Serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 3; Cell Growth-Inhibiting Gene 24/25 Protein; Alpha-1-Antichymotrypsin; Serpin A3; AACT; ACT;
Function
Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2.
Biological Process
Biological Process acute-phase responseIEA:UniProtKB-KW
Biological Process inflammatory response1 PublicationNAS:UniProtKB
Biological Process maintenance of gastrointestinal epithelium1 PublicationNAS:UniProtKB
Biological Process negative regulation of endopeptidase activityManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of lipid metabolic process1 PublicationNAS:UniProtKB
Cellular Location
Secreted
PTM
N- and O-glycosylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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