Mouse Anti-SERPINB1 Recombinant Antibody (CBXS-4971) (CBMAB-S2193-CQ)
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Basic Information
Formulations & Storage [For reference only, actual COA shall prevail!]
Target
Acts primarily to protect the cell from proteases released in the cytoplasm during stress or infection. These proteases are important in killing microbes but when released from granules, these potent enzymes also destroy host proteins and contribute to mortality. Regulates the activity of the neutrophil proteases elastase, cathepsin G, proteinase-3, chymase, chymotrypsin, and kallikrein-3 (PubMed:11747453, PubMed:30692621).
Acts also as a potent intracellular inhibitor of GZMH by directly blocking its proteolytic activity (PubMed:23269243).
During inflammation, limits the activity of inflammatory caspases CASP1, CASP4 and CASP5 by suppressing their caspase-recruitment domain (CARD) oligomerization and enzymatic activation (PubMed:30692621).
When secreted, promotes the proliferation of beta-cells via its protease inhibitory function (PubMed:26701651).
Biological Process negative regulation of interleukin-1 beta productionManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process type B pancreatic cell proliferationManual Assertion Based On ExperimentIDA:UniProtKB
Cytoplasm
Cytolytic granule
Early endosome
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Please try the standard protocols which include: protocols, troubleshooting and guide.
Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols
Antibody Pairs
SERPINB1 Matched Antibody Pair (1066) (CAT#: APMAB-1066LY)
SERPINB1 Matched Antibody Pair (1068) (CAT#: APMAB-1068LY)
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SERPINB1 Matched Antibody Pair (1066) (CAT#: APMAB-1066LY)
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Custom Antibody Labeling
We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).
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