SERPINB1
The protein encoded by this gene is a member of the serpin family of proteinase inhibitors. Members of this family maintain homeostasis by neutralizing overexpressed proteinase activity through their function as suicide substrates. This protein inhibits the neutrophil-derived proteinases neutrophil elastase, cathepsin G, and proteinase-3 and thus protects tissues from damage at inflammatory sites. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
Full Name
Serpin Family B Member 1
Function
Neutrophil serine protease inhibitor that plays an essential role in the regulation of the innate immune response, inflammation and cellular homeostasis (PubMed:30692621).
Acts primarily to protect the cell from proteases released in the cytoplasm during stress or infection. These proteases are important in killing microbes but when released from granules, these potent enzymes also destroy host proteins and contribute to mortality. Regulates the activity of the neutrophil proteases elastase, cathepsin G, proteinase-3, chymase, chymotrypsin, and kallikrein-3 (PubMed:11747453, PubMed:30692621).
Acts also as a potent intracellular inhibitor of GZMH by directly blocking its proteolytic activity (PubMed:23269243).
During inflammation, limits the activity of inflammatory caspases CASP1, CASP4 and CASP5 by suppressing their caspase-recruitment domain (CARD) oligomerization and enzymatic activation (PubMed:30692621).
When secreted, promotes the proliferation of beta-cells via its protease inhibitory function (PubMed:26701651).
Acts primarily to protect the cell from proteases released in the cytoplasm during stress or infection. These proteases are important in killing microbes but when released from granules, these potent enzymes also destroy host proteins and contribute to mortality. Regulates the activity of the neutrophil proteases elastase, cathepsin G, proteinase-3, chymase, chymotrypsin, and kallikrein-3 (PubMed:11747453, PubMed:30692621).
Acts also as a potent intracellular inhibitor of GZMH by directly blocking its proteolytic activity (PubMed:23269243).
During inflammation, limits the activity of inflammatory caspases CASP1, CASP4 and CASP5 by suppressing their caspase-recruitment domain (CARD) oligomerization and enzymatic activation (PubMed:30692621).
When secreted, promotes the proliferation of beta-cells via its protease inhibitory function (PubMed:26701651).
Biological Process
Biological Process negative regulation of endopeptidase activityManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of interleukin-1 beta productionManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process type B pancreatic cell proliferationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of interleukin-1 beta productionManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process type B pancreatic cell proliferationManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Secreted
Cytoplasm
Cytolytic granule
Early endosome
Cytoplasm
Cytolytic granule
Early endosome
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Anti-SERPINB1 antibodies
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CompareTarget: SERPINB1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 4D7
Application*: WB, E
Target: SERPINB1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 4A7
Application*: WB, E
Target: SERPINB1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXS-1351
Application*: WB, P, F, IF
Target: SERPINB1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXS-1350
Application*: WB, F
Target: SERPINB1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-1136
Application*: WB, IP
Target: SERPINB1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-1128
Application*: E
Target: SERPINB1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBXS-0963
Application*: SE, WB, E, WB
Target: SERPINB1
Host: Mouse
Specificity: Human
Clone: CBXS-0235
Application*: WB, IC, P, C, E
Target: SERPINB1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-5123
Application*: WB, IP
Target: SERPINB1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBXS-5022
Application*: WB, IP, IF, E
Target: SERPINB1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-4983
Application*: F, P, WB
Target: SERPINB1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXS-4971
Application*: E, WB
Target: SERPINB1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4953
Application*: E
Target: SERPINB1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Rat, Dog
Clone: CBXS-4774
Application*: WB, F, IH, P
Target: SERPINB1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-4478
Application*: WB
Target: SERPINB1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXS-4392
Application*: F, P, WB
Target: SERPINB1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4372
Application*: WB
Target: SERPINB1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXS-3953
Application*: F, IF, WB
Target: SERPINB1
Specificity: Human
Target: SERPINB1
Specificity: Human
Target: SERPINB1
Specificity: Human
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(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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