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Mouse Anti-SERPINB1 Recombinant Antibody (4A7) (CBMAB-A7995-LY)

The product is antibody recognizes SERPINB1. The antibody 4A7 immunoassay techniques such as: WB, ELISA.
See all SERPINB1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
4A7
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
SERPINB1 (AAH09015, 1 a.a. ~ 379 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Serpin Family B Member 1
Entrez Gene ID
1992
UniProt ID
P30740
Alternative Names
EI; ELANH2; LEI; M/NEI; MNEI; PI2
Function
Neutrophil serine protease inhibitor that plays an essential role in the regulation of the innate immune response, inflammation and cellular homeostasis (PubMed:30692621).
Acts primarily to protect the cell from proteases released in the cytoplasm during stress or infection. These proteases are important in killing microbes but when released from granules, these potent enzymes also destroy host proteins and contribute to mortality. Regulates the activity of the neutrophil proteases elastase, cathepsin G, proteinase-3, chymase, chymotrypsin, and kallikrein-3 (PubMed:11747453, PubMed:30692621).
Acts also as a potent intracellular inhibitor of GZMH by directly blocking its proteolytic activity (PubMed:23269243).
During inflammation, limits the activity of inflammatory caspases CASP1, CASP4 and CASP5 by suppressing their caspase-recruitment domain (CARD) oligomerization and enzymatic activation (PubMed:30692621).
When secreted, promotes the proliferation of beta-cells via its protease inhibitory function (PubMed:26701651).
Biological Process
Biological Process negative regulation of endopeptidase activityManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of interleukin-1 beta productionManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process type B pancreatic cell proliferationManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Secreted
Cytoplasm
Cytolytic granule
Early endosome
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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